Microfluidics for Manipulating Cells

被引：173
作者：
Mu, Xuan [1 ,2 ]
Zheng, Wenfu [1 ]
Sun, Jiashu [1 ]
Zhang, Wei [1 ]
Jiang, Xingyu [1 ]
机构：
[1] Chinese Acad Sci, Key Lab Biol Effects Nanomat & Nanosafety, Natl Ctr NanoSci & Technol, Beijing 100190, Peoples R China
[2] Chinese Acad Med Sci, Peking Union Med Coll, Inst Basic Med Sci, Sch Basic Med, Beijing 100005, Peoples R China
来源：
SMALL | 2013年 / 9卷 / 01期
基金：
美国国家科学基金会; 中国博士后科学基金;
关键词：
microfluidics; cells; diagnostics; patterning; screening; CIRCULATING TUMOR-CELLS; SELF-ASSEMBLED MONOLAYERS; INTEGRATED CHAOTIC MICROMIXERS; PATTERNING MULTIPLE TYPES; SINGLE-MOLECULE LEVEL; ON-A-CHIP; MAMMALIAN-CELLS; EFFICIENT CAPTURE; CANCER-CELLS; WHOLE-BLOOD;
D O I：
10.1002/smll.201200996
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Microfluidics, a toolbox comprising methods for precise manipulation of fluids at small length scales (micrometers to millimeters), has become useful for manipulating cells. Its uses range from dynamic management of cellular interactions to high-throughput screening of cells, and to precise analysis of chemical contents in single cells. Microfluidics demonstrates a completely new perspective and an excellent practical way to manipulate cells for solving various needs in biology and medicine. This review introduces and comments on recent achievements and challenges of using microfluidics to manipulate and analyze cells. It is believed that microfluidics will assume an even greater role in the mechanistic understanding of cell biology and, eventually, in clinical applications.
引用
收藏
页码：9 / 21
页数：13
相关论文
共 224 条
  • [11] Pinched flow coupled shear-modulated inertial microfluidics for high-throughput rare blood cell separation
    Bhagat, Ali Asgar S.
    Hou, Han Wei
    Li, Leon D.
    Lim, Chwee Teck
    Han, Jongyoon
    [J]. LAB ON A CHIP, 2011, 11 (11) : 1870 - 1878
  • [12] Droplet microfluidic technology for single-cell high-throughput screening
    Brouzes, Eric
    Medkova, Martina
    Savenelli, Neal
    Marran, Dave
    Twardowski, Mariusz
    Hutchison, J. Brian
    Rothberg, Jonathan M.
    Link, Darren R.
    Perrimon, Norbert
    Samuels, Michael L.
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (34) : 14195 - 14200
  • [13] Fabrication of a modular tissue construct in a microfluidic chip
    Bruzewicz, Derek A.
    McGuigan, Alison P.
    Whitesides, George M.
    [J]. LAB ON A CHIP, 2008, 8 (05) : 663 - 671
  • [14] Butler DL, 2009, TISSUE ENG PART B-RE, V15, P477, DOI [10.1089/ten.teb.2009.0340, 10.1089/ten.TEB.2009.0340]
  • [15] Stochastic protein expression in individual cells at the single molecule level
    Cai, L
    Friedman, N
    Xie, XS
    [J]. NATURE, 2006, 440 (7082) : 358 - 362
  • [16] Microfluidic high-throughput encapsulation and hydrodynamic self-sorting of single cells
    Chabert, Max
    Viovy, Jean-Louis
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (09) : 3191 - 3196
  • [17] Programmable cell adhesion encoded by DNA hybridization
    Chandra, RA
    Douglas, ES
    Mathies, RA
    Bertozzi, CR
    Francis, MB
    [J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2006, 45 (06) : 896 - 901
  • [18] A novel multishear microdevice for studying cell mechanics
    Chau, Lien
    Doran, Michael
    Cooper-White, Justin
    [J]. LAB ON A CHIP, 2009, 9 (13) : 1897 - 1902
  • [19] Geometric control of cell life and death
    Chen, CS
    Mrksich, M
    Huang, S
    Whitesides, GM
    Ingber, DE
    [J]. SCIENCE, 1997, 276 (5317) : 1425 - 1428
  • [20] Nanoporous Elements in Microfluidics for Multiscale Manipulation of Bioparticles
    Chen, Grace D.
    Fachin, Fabio
    Fernandez-Suarez, Marta
    Wardle, Brian L.
    Toner, Mehmet
    [J]. SMALL, 2011, 7 (08) : 1061 - 1067
12345678910