Microfluidics for Manipulating Cells

被引：178

作者：

Mu, Xuan ^{[1
,2
]}

Zheng, Wenfu ^{[1
]}

Sun, Jiashu ^{[1
]}

Zhang, Wei ^{[1
]}

Jiang, Xingyu ^{[1
]}

机构：

[1] Chinese Acad Sci, Key Lab Biol Effects Nanomat & Nanosafety, Natl Ctr NanoSci & Technol, Beijing 100190, Peoples R China

[2] Chinese Acad Med Sci, Peking Union Med Coll, Inst Basic Med Sci, Sch Basic Med, Beijing 100005, Peoples R China

来源：

SMALL | 2013年 / 9卷 / 01期

基金：

中国博士后科学基金; 美国国家科学基金会;

关键词：

microfluidics; cells; diagnostics; patterning; screening; CIRCULATING TUMOR-CELLS; SELF-ASSEMBLED MONOLAYERS; INTEGRATED CHAOTIC MICROMIXERS; PATTERNING MULTIPLE TYPES; SINGLE-MOLECULE LEVEL; ON-A-CHIP; MAMMALIAN-CELLS; EFFICIENT CAPTURE; CANCER-CELLS; WHOLE-BLOOD;

D O I：

10.1002/smll.201200996

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Microfluidics, a toolbox comprising methods for precise manipulation of fluids at small length scales (micrometers to millimeters), has become useful for manipulating cells. Its uses range from dynamic management of cellular interactions to high-throughput screening of cells, and to precise analysis of chemical contents in single cells. Microfluidics demonstrates a completely new perspective and an excellent practical way to manipulate cells for solving various needs in biology and medicine. This review introduces and comments on recent achievements and challenges of using microfluidics to manipulate and analyze cells. It is believed that microfluidics will assume an even greater role in the mechanistic understanding of cell biology and, eventually, in clinical applications.

引用

页码：9 / 21

页数：13

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