Ligand-Controlled Nickel-Catalyzed Tandem Isomerization/Regiodivergent Hydroheteroarylation of α-Alkenes with Heteroarenes

被引：5

作者：

Imran, Sajid ^{[1
]}

Jin, Wen-Hui ^{[1
]}

Li, Rui-Peng ^{[1
]}

Ismaeel, Nadia ^{[1
]}

Sun, Hong-Mei ^{[1
]}

机构：

[1] Soochow Univ, Coll Chem & Chem Engn, Key Lab Organ Synth Jiangsu Prov, Suzhou 215123, Jiangsu, Peoples R China

来源：

ORGANIC LETTERS | 2022年 / 24卷 / 48期

基金：

中国国家自然科学基金;

关键词：

REGIOSELECTIVE HYDROHETEROARYLATION; ISOMERIZATION; ACTIVATION;

D O I：

10.1021/acs.orglett.2c03689

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We herein describe an accessible ligand-controlled nickel-catalyzed tandem isomerization/regiodivergent hydroheteroarylation of alpha-alkenes with a series of heteroarenes, wherein the NHC ligand of heteroleptic Ni(II) complexes of the type Ni(NHC)[P(OEt)(3)]Br-2 displayed significant effects on regulation. In the presence of (NaOBu)-Bu-t, Ni(IMes)[P(OEt)(3)]Br-2 enables C=C bond isomerization of alpha-alkenes over up to four sp(3) carbon atoms to afford branched products, while Ni(IPr*(OMe))[P(OEt)(3)]Br-2 greatly deactivates alpha-alkene isomerization and favors the formation of linear products.

引用

页码：8875 / 8879

页数：5