Ureasil-polyether hybrid film-forming materials

被引：22
|
作者：
Souza, L. K. [1 ,2 ]
Bruno, C. H. [1 ,3 ]
Lopes, L. [4 ]
Pulcinelli, S. H. [4 ]
Santilli, C. V. [4 ]
Chiavacci, L. A. [1 ]
机构：
[1] Univ Estadual Paulista, Fac Ciencias Farmaceut, BR-14801902 Sao Paulo, Brazil
[2] Johnson & Johnson Consumer Co, Sao Paulo, Brazil
[3] UFES, Dept Hlth Sci, Sao Mateus, ES, Brazil
[4] Univ Estadual Paulista, Inst Chem, BR-14801902 Sao Paulo, Brazil
来源：
COLLOIDS AND SURFACES B-BIOINTERFACES | 2013年 / 101卷
关键词：
Film-forming material; Hybrid materials; Sol-gel; PERCUTANEOUS-ABSORPTION; IN-VITRO; OCCLUSION; DELIVERY; VEHICLE; INVITRO; VIVO; MTT;
D O I：
10.1016/j.colsurfb.2012.06.009
中图分类号：
Q6 [生物物理学];
学科分类号：
071011 ;
摘要：
The objectives of this work were to study the suitability and highlight the advantages of the use of cross-linked ureasil polyether hybrid matrices as film-forming systems. The results revealed that ureasil polyethers are excellent film-forming systems due to specific properties, such as their biocompatibility, their cosmetic attractiveness for being able to form thin and transparent films, their short drying time to form films and their excellent bioadhesion compared to the commercial products known as strong adhesives. Rheological measurements have demonstrated the ability of these hybrid matrices to form a film in only a few seconds and Water Vapor Transmitting Rate (WVTR) showed adequate semi-occlusive properties suggesting that these films could be used as skin and wound protectors. Both the high skin bioadhesion and non-cytotoxic character seems to be improved by the presence of multiple amine groups in the hybrid molecules. (C) 2012 Elsevier B.V. All rights reserved.
引用
收藏
页码：156 / 161
页数：6
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