Opposing and potentially antagonistic effects of BMP and TGF-β in multiple sclerosis: The "Yin and Yang" of neuro-immune Signaling

被引：7

作者：

Sotiropoulos, Marinos G. ^{[1
,2
]}

Chitnis, Tanuja ^{[1
,2
]}

机构：

[1] Harvard Med Sch, Boston, MA 02115 USA

[2] Brigham & Womens Hosp, Ann Romney Ctr Neurol Dis, Dept Neurol, 60 Fenwood Rd, Boston, MA 02115 USA

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2020年 / 347卷

关键词：

Bone morphogenetic proteins; Transforming growth factor beta; Multiple sclerosis; Remyelination; Inflammation; Reciprocal antagonism; BONE-MORPHOGENETIC PROTEIN; GROWTH-FACTOR-BETA; REGULATORY T-CELLS; SERUM-LEVELS; SPINAL-CORD; TGF-BETA-2; EXPRESSION; ACTIVATION; INHIBITION; PATHWAY;

D O I：

10.1016/j.jneuroim.2020.577358

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Bone Morphogenetic Proteins (BMP) and Transforming Growth Factor-beta (TGF-beta) are cytokines with similar receptors and messengers. They are important for immune cell function, with BMPs exerting mainly proinflammatory but also anti-inflammatory effects, and TGF-beta suppressing inflammation. Patients with Multiple Sclerosis exhibit BMP overactivity and suppressed TGF-beta signaling. This dysregulated signaling participates in the crosstalk between infiltrating immune cells and glia, where BMP inhibits remyelination. Reciprocal antagonism between the two pathways takes place via a variety of mechanisms. Although this antagonism has not been studied in the setting of Multiple Sclerosis, it could inform further research and treatment discovery.

引用

页数：8

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