Decisional procalcitonin thresholds are not adapted to elderly patients admitted to the emergency room

被引：27

作者：

Chenevier-Gobeaux, Camille ^{[1
]}

Trabattoni, Eloise ^{[2
,3
]}

Elfassy, Yaelle ^{[1
]}

Picard, Camille ^{[1
]}

Guerin, Sylvie ^{[1
]}

Borderie, Didier ^{[1
,4
]}

Claessens, Yann-Erick ^{[2
,3
,5
]}

机构：

[1] Grp Hosp Cochin Broca Hotel Dieu, APHP, Dept Biochem, F-75014 Paris, France

[2] Grp Hosp Cochin Broca Hotel Dieu, APHP, Dept Emergency Med, F-75014 Paris, France

[3] Univ Paris 05, Fac Med, Paris, France

[4] Univ Paris 05, EA4466, Fac Pharm, Sorbonne Paris Cite, Paris, France

[5] Ctr Hosp Princesse Grace, Dept Emergency Med, Monaco, Monaco

来源：

BIOMARKERS | 2012年 / 17卷 / 05期

关键词：

Procalcitonin; reference values; infection; elderly; immune senescence; emergency medicine; PROATRIAL NATRIURETIC PEPTIDE; RENAL-DISEASE; INFECTION; DIAGNOSIS; COAGULATION; MARKERS; SEPSIS;

D O I：

10.3109/1354750X.2012.685953

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Context: Diagnosis of sepsis in elderly is challenging. Objectives: We investigated whether procalcitonin concentrations in elderly differed from values for the general population. Methods: Procalcitonin measurement was assessed prospectively in 307 apyretic patients >= 75 years visiting the emergency department. Results: Median age was 86 years [IQR81-90] and 222 (72%) were female. Procalcitonin concentration was 0.057 mu g/L [0.040-0.092]; 99th percentile was 0.661 mu g/L. Patients with procalcitonin concentrations above decisional thresholds had lower glomerular filtration rate and higher C-reactive protein concentrations. Conclusions: Baseline procalcitonin levels are increased in elderly. Elevated values are common and associated to low-grade inflammation and lower eGFR.

引用

页码：477 / 481

页数：5

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