The Sex Influence on Response to Tumor Necrosis Factor-α Inhibitors and Remission in Axial Spondyloarthritis

被引:52
作者
Lubrano, Ennio [1 ]
Perrotta, Fabio Massimo [1 ]
Manara, Maria [6 ]
D'Angelo, Salvatore [2 ,3 ]
Addimanda, Olga [4 ]
Ramonda, Roberta [7 ]
Punzi, Leonardo [7 ]
Olivieri, Ignazio [2 ,3 ]
Salvarani, Carlo [5 ,8 ]
Marchesoni, Antonio [6 ]
机构
[1] Univ Molise, Dipartimento Med & Sci Salute Vincenzo Tiberio, Via Giovanni Paolo 2, I-86100 Campobasso, Italy
[2] San Carlo Hosp Potenza, Rheumatol Dept Lucania, Matera, Italy
[3] Madonna Grazie Hosp Matera, Matera, Italy
[4] Univ Bologna, Ist Ortoped Rizzoli, SSD Med & Rheumatol, Bologna, Italy
[5] Univ Modena & Reggio Emilia, Reggio Emilia, Italy
[6] ASST Ctr Specialist Ortoped Traumatol G Pini CTO, Day Hosp Rheumatol, Milan, Italy
[7] Univ Padua, DIMED, Rheumatol Unit, Padua, Italy
[8] IRCCS Reggio Emilia, Reggio Emilia, Italy
关键词
SPONDYLOARTHRITIS; REMISSION; RESPONSE TO TREATMENT; ANTITUMOR NECROSIS FACTOR-alpha DRUGS; ACTIVITY SCORE ASDAS; ANKYLOSING-SPONDYLITIS; CLASSIFICATION CRITERIA; GENDER-DIFFERENCES; DISEASE; WOMEN; BATH; IMPROVEMENT; EFFICACY; SAFETY;
D O I
10.3899/jrheum.170666
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective. The aim of this study was to evaluate the influence of sex on response to treatment and disease remission in patients with axial spondyloarthritis (axSpA). Methods. In this retrospective multicenter study, patients with axSpA, according to the Assessment of Spondyloarthritis international Society (ASAS) criteria for axSpA, and treated with adalimumab, etanercept, golimumab, or infliximab, were studied. We compared clinical characteristics, patient-reported outcomes, disease activity, function, and response to treatment in male and female patients with this disease. Results. Three hundred forty patients with axSpA (270 with ankylosing spondylitis, 19 with psoriatic arthritis with axial involvement, and 51 with nonradiographic axSpA) were studied. Male subjects had a significantly higher prevalence of grade IV sacroiliitis, higher levels of serum C-reactive protein, lower Maastricht Ankylosing Spondylitis Enthesitis Score, and fatigue when compared with females. Further, Kaplan-Meier survival curves showed that the rate of partial remission, ASAS40 response, and Ankylosing Spondylitis Disease Activity Score (ASDAS) major improvement, but not ASDAS inactive disease, were significantly lower in female patients. Conclusion. Our data suggest that female sex was associated with a lower rate of response to treatment and of disease remission in patients with axSpA treated with antitumor necrosis factor-alpha drugs.
引用
收藏
页码:195 / 201
页数:7
相关论文
共 36 条
[1]   Fibromyalgia in women with ankylosing spondylitis [J].
Aloush, Valerie ;
Ablin, Jacob N. ;
Reitblat, Tatiana ;
Caspi, Dan ;
Elkayam, Ori .
RHEUMATOLOGY INTERNATIONAL, 2007, 27 (09) :865-868
[2]  
Anderson JJ, 2001, ARTHRITIS RHEUM-US, V44, P1876, DOI 10.1002/1529-0131(200108)44:8<1876::AID-ART326>3.0.CO
[3]  
2-F
[4]   Baseline predictors of response and discontinuation of tumor necrosis factor-alpha blocking therapy in ankylosing spondylitis: a prospective longitudinal observational cohort study [J].
Arends, Suzanne ;
Brouwer, Elisabeth ;
van der Veer, Eveline ;
Groen, Henk ;
Leijsma, Martha K. ;
Houtman, Pieternella M. ;
Jansen, Tim L. Th A. ;
Kallenberg, Cees G. M. ;
Spoorenberg, Anneke .
ARTHRITIS RESEARCH & THERAPY, 2011, 13 (03)
[5]   Non-radiographic axial spondyloarthritis and ankylosing spondylitis: what are the similarities and differences? [J].
Baraliakos, X. ;
Braun, J. .
RMD OPEN, 2015, 1
[6]  
CALIN A, 1994, J RHEUMATOL, V21, P2281
[7]   The term 'non-radiographic axial spondyloarthritis' is much more important to classify than to diagnose patients with axial spondyloarthritis [J].
Deodhar, Atul ;
Strand, Vibeke ;
Kay, Jonathan ;
Braun, Juergen .
ANNALS OF THE RHEUMATIC DISEASES, 2016, 75 (05) :791-794
[8]   Eight-Year Retention Rate of First-Line Tumor Necrosis Factor Inhibitors in Spondyloarthritis: A Multicenter Retrospective Analysis [J].
Favalli, Ennio Giulio ;
Selmi, Carlo ;
Becciolini, Andrea ;
Biggioggero, Martina ;
Ariani, Alarico ;
Santilli, Daniele ;
Fusaro, Enrico ;
Parisi, Simone ;
Massarotti, Marco ;
Marchesoni, Antonio ;
Meroni, Pier Luigi .
ARTHRITIS CARE & RESEARCH, 2017, 69 (06) :867-874
[9]   Sex:: a major predictor of remission in early rheumatoid arthritis? [J].
Forslind, K. ;
Hafstrom, I. ;
Ahlmen, M. ;
Svensson, B. .
ANNALS OF THE RHEUMATIC DISEASES, 2007, 66 (01) :46-52
[10]  
GARRETT S, 1994, J RHEUMATOL, V21, P2286