Ultraviolet B-induced LGI3 secretion protects human keratinocytes

被引：20

作者：

Lee, Seung Hoon ^{[1
]}

Jeong, Yun-Mi ^{[1
]}

Kim, So-Young ^{[1
]}

Jeong, Hyo-Soon ^{[1
]}

Park, Kyoung-Chan ^{[2
]}

Baek, Kwang Jin ^{[1
]}

Kwon, Nyoun Soo ^{[1
]}

Yun, Hye-Young ^{[1
]}

Kim, Dong-Seok ^{[1
]}

机构：

[1] Chung Ang Univ, Dept Biochem, Coll Med, Seoul 156756, South Korea

[2] Seoul Natl Univ, Dept Dermatol, Bundang Hosp, Songnam, Gyeonggi Do, South Korea

来源：

EXPERIMENTAL DERMATOLOGY | 2012年 / 21卷 / 09期

关键词：

chronic allergic contact dermatitis; H1 receptor antagonist; H4 receptor antagonist; CONTACT-DERMATITIS; HISTAMINE; CHEMOTAXIS;

D O I：

10.1111/j.1600-0625.2012.01550.x

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Histamine facilitates development of eczematous lesions in chronic allergic contact dermatitis. In addition to the well-known corticosteroid treatments, H1 receptor (H1R) antagonists also have been used. This study observed effects of histamine H4 receptor (H4R) antagonist usage with H1R antagonist in a murine chronic allergic contact dermatitis model, developed by repeated percutaneous challenge to the dorsal skin with 2,4,6-trinitro-1-chlorobenzene (TNCB). The H1R antagonist olopatadine hydrochloride and/or the H4R antagonist JNJ7777120 was then administered. Combination therapy was more effective than H1R antagonist monotherapy. Serum IgE and levels of interleukin (IL)-4, IL-5 and IL-6 (Th2 cytokines) in eczematous lesions decreased with combined therapy. Combined therapy with H1R and H4R antagonists counteracts the disadvantages of each as monotherapeutic agents and potentially represents a new strategy for the treatment of chronic allergic contact dermatitis.

引用

页码：716 / 718

页数：3

共 18 条

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