Investigation of the toxic potential of crude ethanol extract of Annona coriacea (araticum) seeds in acute exposed mice

被引：6

作者：

do Nascimento, Guilherme Nobre L. ^{[2
]}

Valadares, Marize Campos ^{[2
]}

Nishijo, Hisao ^{[1
]}

Aversi-Ferreira, Tales Alexandre ^{[1
]}

机构：

[1] Toyama Univ, Grad Sch Med & Pharmaceut Sci, Toyama 9300194, Japan

[2] Univ Fed Goias, Lab Farmacol Celular & Toxicol, Goiania, Go, Brazil

来源：

REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY | 2012年 / 22卷 / 03期

关键词：

Annonaceae; Annona coriacea; araticum; hepatotoxicity; plant toxicity; MITOCHONDRIAL COMPLEX-I; ATYPICAL PARKINSONISM; ACETOGENIN; CYTOTOXICITY; GUADELOUPE; BULLATACIN; INHIBITORS; LECTIN; PLANTS; BRAZIL;

D O I：

10.1590/S0102-695X2012005000015

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

In this study, Annona coriacea Mart., Annonaceae, was examined for possible toxic effects on brain, liver and kidney of mice exposed to crude extract of the seeds (CESAN) of this plant. CESAN was administered by gavage for four days at doses of 12.5, 25, 50, and 100 mg/kg/day. Significant changes on liver were observed, which showed reduction in the number of hepatocytes per area and increase the apoptotic index in the exposed groups, and changes in the cytoplasm and nucleus of these cells and reduced consumption of water and feed in these animals. For the other studied areas, brain and kidneys showed no changes in the parameters used in this study. The results suggest hepatotoxic effects of CESAN, but without damage to brain and kidneys in this experiment, showing a toxic potential to this species, as to the Annonaceae family.

引用

页码：580 / 586

页数：7

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