Total synthesis of (S)-(+)-curcudiol, and (S)-(+)- and (R)-(-)-curcuphenol

被引：29

作者：

Ono, M ^{[1
]}

Ogura, Y ^{[1
]}

Hatogai, K ^{[1
]}

Akita, H ^{[1
]}

机构：

[1] Toho Univ, Sch Pharmaceut Sci, Funabashi, Chiba 2748510, Japan

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2001年 / 49卷 / 12期

关键词：

bisabolane sesquiterpene; enantioselective hydrolysis; lipase; total synthesis;

D O I：

10.1248/cpb.49.1581

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A highly enantioselective synthesis of the versatile chiral synthons possessing one stereogenic center, (S)-and (R)-4-aryl-5-hydroxy-(2E)-pentenoate (3) was achieved based on the enzymatic reaction of (+/-)-3 with commercially available lipases MY-30 or OF-360 from Candida rugosa. Application of (S)-3 and (R)-3 to the total syntheses of (S)-curcuphenol (1), (S)-curcudiol (2), and (R)-curcuphenol (1), respectively, is described.

引用

页码：1581 / 1585

页数：5

共 16 条

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