miRNA profiling in gastrointestinal stromal tumors: implication as diagnostic and prognostic markers

被引：23

作者：

Nannini, Margherita ^{[1
]}

Ravegnini, Gloria ^{[2
]}

Angelini, Sabrina ^{[2
]}

Astolfi, Annalisa ^{[3
]}

Biasco, Guido ^{[1
,3
]}

Pantaleo, Maria A. ^{[1
,3
]}

机构：

[1] Univ Bologna, St Orsola Malpighi Hosp, Dept Specialized Expt & Diagnost Med, Bologna, Italy

[2] Univ Bologna, FaBit, Dept Pharm & Biotechnol, Bologna, Italy

[3] Univ Bologna, Giorgio Prodi Canc Res Ctr, Bologna, Italy

来源：

EPIGENOMICS | 2015年 / 7卷 / 06期

关键词：

gastrointestinal stromal tumors; KIT; microRNA; PDGFRA; wild-type; MICRORNA EXPRESSION SIGNATURE; CELL LUNG-CANCER; DOWN-REGULATION; UP-REGULATION; UNFAVORABLE PROGNOSIS; THERAPEUTIC TARGET; COLORECTAL-CANCER; GASTRIC-CANCER; PROGRESSION; IMATINIB;

D O I：

10.2217/epi.15.52

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

MicroRNAs are a class of short noncoding RNAs, that play a relevant role in multiple biological processes, such as differentiation, proliferation and apoptosis. Gastrointestinal stromal tumors (GIST) are considered as a paradigm of molecular biology in solid tumors worldwide, and after the discovery of specific alterations in the KIT and PDGFRA genes, they have emerged from anonymity to become a model for targeted therapy. Epigenetics have an emerging and relevant role in different steps of GIST biology such as tumorigenesis, disease progression, prognosis and drug resistance. The aim of the present review was to summarize the current evidence about the role of microRNAs in GIST, including their potential application as well as their limits.

引用

页码：1033 / 1049

页数：17

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