Amyloid-Hydroxyapatite Bone Biomimetic Composites

被引：199

作者：

Li, Chaoxu ^{[1
]}

Born, Anne-Kathrin ^{[2
]}

Schweizer, Thomas ^{[4
]}

Zenobi-Wong, Marcy ^{[2
]}

Cerruti, Marta ^{[3
]}

Mezzenga, Raffaele ^{[1
]}

机构：

[1] ETH, Dept Hlth Sci & Technol, LFO, CH-8092 Zurich, Switzerland

[2] ETH, Dept Hlth Sci & Technol, HPL, CH-8093 Zurich, Switzerland

[3] McGill Univ, Biointerface Lab, Dept Min & Mat Engn, Montreal, PQ H3A 0C5, Canada

[4] ETH, Dept Mat, CH-8093 Zurich, Switzerland

来源：

ADVANCED MATERIALS | 2014年 / 26卷 / 20期

关键词：

CALCIUM-PHOSPHATE; MINERALIZED COLLAGEN; SENSING PROPERTIES; APATITE; FIBRILS; NANOCOMPOSITES; NUCLEATION; PROTEINS; GRAPHENE; GROWTH;

D O I：

10.1002/adma.201306198

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A "bottom up" strategy is proposed to synthesize high aspect ratio hydroxyapatite (and brushite) platelets, and combine them with amyloid fibrils into layered hybrid nanocomposites. Their hierarchical structure, despite the differences from natural bone, confers to the nanocomposites a density and elastic modulus matching those of cancellous bone. Evidence of good adhesion and spreading of human trabecular bone-derived pre-osteoblasts cells on these nanocomposites is provided.

引用

页码：3207 / +

页数：7

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