Human papillomaviruses: a growing field

被引：9

作者：

Galloway, Denise A. ^{[1
]}

机构：

[1] Fred Hutchinson Canc Res Ctr, Human Biol Div, Seattle, WA 98109 USA

来源：

GENES & DEVELOPMENT | 2009年 / 23卷 / 02期

关键词：

Human papillomavirus infection program; organotypic cultures of primary human keratinocytes; Cre-loxP-mediated recombination in vivo; cell cycle regulation; immortalization- and replication-defective E6 mutant; p53 protein stabilization; KERATINOCYTE CELL-LINE; VIRAL GENOME AMPLIFICATION; LIFE-CYCLE; EPITHELIAL DIFFERENTIATION; IN-VITRO; TYPE-16; E7; INFECTION; DNA; REPLICATION;

D O I：

10.1101/gad.1765809

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

A combination of functional studies on human papillomavirus (HPV) oncoproteins and epidemiological studies on persistence of HPV infection firmly established a role for HPV in the etiology of cervical cancers. Understanding the viral life cycle of HPVs has been more difficult. In this issue of Genes & Development, Wang et al. (pp. 181-194) describe an efficient method to propagate infectious HPV in differentiating epithelium, providing clear evidence for temporal separation of viral and cellular replication.

引用

页码：138 / 142

页数：5

共 39 条

[1]

Baker Carl C., 1993, P134

[2] AMPLIFICATION OF HUMAN PAPILLOMAVIRUS GENOMES INVITRO IS DEPENDENT ON EPITHELIAL DIFFERENTIATION [J].

BEDELL, MA ;

HUDSON, JB ;

GOLUB, TR ;

TURYK, ME ;

HOSKEN, M ;

WILBANKS, GD ;

LAIMINS, LA .

JOURNAL OF VIROLOGY, 1991, 65 (05) :2254-2260

[3]

BLANTON RA, 1991, AM J PATHOL, V138, P673

[4]

BLANTON RA, 1992, CELL GROWTH DIFFER, V3, P791

[5]

Buck CB, 2005, METH MOLEC MED, V119, P445

[6] Efficient intracellular assembly of papillomaviral vectors [J].

Buck, CB ;

Pastrana, DV ;

Lowy, DR ;

Schiller, JT .

JOURNAL OF VIROLOGY, 2004, 78 (02) :751-757

[7] Comparison of human papillomavirus types 16, 18, and 6 capsid antibody responses following incident infection [J].

Carter, JJ ;

Koutsky, LA ;

Hughes, JP ;

Lee, SK ;

Kuypers, J ;

Kiviat, N ;

Galloway, DA .

JOURNAL OF INFECTIOUS DISEASES, 2000, 181 (06) :1911-1919

[8] DIFFERENTIATION-DEPENDENT UP-REGULATION OF THE HUMAN PAPILLOMAVIRUS E7 GENE REACTIVATES CELLULAR DNA-REPLICATION IN SUPRABASAL DIFFERENTIATED KERATINOCYTES [J].

CHENG, S ;

SCHMIDTGRIMMINGER, DC ;

MURANT, T ;

BROKER, TR ;

CHOW, LT .

GENES & DEVELOPMENT, 1995, 9 (19) :2335-2349

[9] Human papillornavirus type 16 E1∧E4-induced G2 arrest is associated with cytoplasmic retention of active Cdk1/Cyclin B1 complexese [J].

Davy, CE ;

Jackson, DJ ;

Raj, K ;

Peh, WL ;

Southern, SA ;

Das, P ;

Sorathia, R ;

Laskey, P ;

Middleton, K ;

Nakahara, T ;

Wang, Q ;

Masterson, PJ ;

Lambert, PF ;

Cuthill, S ;

Millar, JBA ;

Doorbar, J .

JOURNAL OF VIROLOGY, 2005, 79 (07) :3998-4011

[10] G2/M cell cycle arrest in the life cycle of viruses [J].

Davy, Clare ;

Doorbar, John .

VIROLOGY, 2007, 368 (02) :219-226

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