Neural expression profile of α-synuclein in developing human cortex

被引：57

作者：

Bayer, TA

Jäkälä, P

Hartmann, T

Egensperger, R

Buslei, R

Falkai, P

Beyreuther, K

机构：

[1] Univ Bonn, Dept Psychiat, Med Ctr, D-53105 Bonn, Germany

[2] ZMBH, D-69120 Heidelberg, Germany

[3] Univ Kuopio, Dept Neurosci & Neurol, FIN-70211 Kuopio, Finland

[4] Kuopio Univ Hosp, Dept Neurosci & Neurol, Kuopio 70211, Finland

[5] Hannover Med Sch, Inst Neuropathol, D-30625 Hannover, Germany

来源：

NEUROREPORT | 1999年 / 10卷 / 13期

关键词：

Alzheimer's disease; Down's syndrome; human fetal brain; immunostaining; NAC; NACP; RT-PCR; trisomy; 21; Western blot;

D O I：

10.1097/00001756-199909090-00019

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

alpha-SYNUCLEIN is a predominantly neuronal presynaptic protein that may play an important role during synaptogenesis and CNS development. In order to elucidate the human developmental expression profile, we used a polyclonal. antiserum against the NAC domain of alpha-synuclein. In normal fetal cortex neuroectodermal precursor cells elicited staining in the soma, whereas, in adult cortex, we observed a staining pattern compatible with synaptic function. The same developmental intraneuronal redistribution was found in neurodegenerative disorders, i.e. somatic staining in neuroectodermal precursors in fetal (trisomy 21) and a synaptic pattern in adult (Do Nn's syndrome, Alzheimer's disease) brains. RT-PCR and Western blot analysis revealed expression at all time points studied (4-7.5 months) during human brain development. (C) 1999 Lippincott Williams & Wilkins.

引用

页码：2799 / 2803

页数：5

共 21 条

[1] α-Synuclein accumulates in Lewy bodies in Parkinson's disease and dementia with Lewy bodies but not in Alzheimer's disease β-amyloid plaque cores [J].