Anticonvulsant and Neuroprotective Effects of Oligosaccharides from Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Higher Basidiomycetes)

被引：31

作者：

Aguirre-Moreno, Alma ^{[1
]}

Villeda-Hernandez, Juana ^{[2
]}

Campos-Pena, Victoria ^{[3
]}

Herrera-Ruiz, Maribel ^{[4
]}

Montiel, Elizur ^{[5
]}

Tello, Isaac ^{[5
]}

del Rio-Portilla, Federico ^{[6
]}

Rodriguez, Veronica ^{[1
]}

Leon-Rivera, Ismael ^{[7
]}

机构：

[1] Univ Autonoma Estado Morelos, Fac Farm, Cuernavaca 62209, Morelos, Mexico

[2] SSA, MVS, Inst Nacl Neurol, Lab Expt Neuropatol, Col La Fama 14269, DF, Mexico

[3] SSA, MVS, Inst Nacl Neurol, Lab Enfermedades Neurodegenerat, Col La Fama 14269, DF, Mexico

[4] Inst Mexicano Seguro Social, Ctr Invest Biomed Sur, Xochitepec 62790, Morelos, Mexico

[5] Univ Autonoma Estado Morelos, Ctr Invest Biol, Cuernavaca 62209, Morelos, Mexico

[6] Univ Nacl Autonoma Mexico, Inst Quim, Coyoacan 04510, DF, Mexico

[7] Univ Autonoma Estado Morelos, Ctr Invest Quim, Cuernavaca 62209, Morelos, Mexico

来源：

INTERNATIONAL JOURNAL OF MEDICINAL MUSHROOMS | 2013年 / 15卷 / 06期

关键词：

medicinal mushrooms; Lingzhi or Reishi mushroom; Ganoderma lucidum; oligosaccharide; neuroprotective; anticonvulsant; TEMPORAL-LOBE EPILEPSY; DRUGS; MODEL;

D O I：

10.1615/IntJMedMushr.v15.i6.40

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

An oligosaccharide fraction isolated from the mycelium of the Lingzhi or Reishi medicinal mushroom Ganoderma lucidwn (GLOS) was separated by size-exclusion chromatography. The chemical structure of GLOS consists of a disaccharide repeating unit [-4-beta-1-Galf(1-6)-O-(beta-Glcp)-1-](n) (n=3,4). In addition, this study was undertaken to determine the possible anticonvulsant and neuroprotective effects of GLOS (10-80 mg/kg) on kainic acid (KA)-induced seizures. The behavioral alterations and histopathology of hippocampal neurons were studied. Our results show that GLOS inhibited convulsions in rats from KA-induced seizures, reduced the degeneration pattern in the CA3 region of rats, decreased astrocytic reactivity, and reduced the expression of IL-1 beta and TNF-alpha induced by KA. These results indicate a potential anticonvulsant and neuroprotective effects of GLOS.

引用

页码：555 / 568

页数：14

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