Atypical chronic myelogenous leukemia following immunosuppressive therapy for severe aplastic anemia

被引：2

作者：

Robak, T ^{[1
]}

Kasznicki, M ^{[1
]}

Strzelecka, B ^{[1
]}

Bartkowiak, J ^{[1
]}

Debiec-Rychter, M ^{[1
]}

机构：

[1] Med Univ Lodz, Dept Hematol, PL-93513 Lodz, Poland

来源：

LEUKEMIA & LYMPHOMA | 1999年 / 35卷 / 1-2期

关键词：

atypical CML; aplastic anemia; immunosuppressive treatment; interferon alpha; clonal complications;

D O I：

10.3109/10428199909145719

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Late clonal complications of aplastic anemia (AA) such as acute leukemia, myelodysplastic syndromes or paroxysmal nocturnal hemoglobinuria have been recognized for a long time. To our knowledge, chronic myelogenous leukemia (CML) as a late complication of severe aplastic anemia has as yet not been reported. We report here a case of AA treated successfully with antilymphocytic globulin and cyclosporin in whom Ph-1 negative, BCR/ABL negative CML developed 8 years after diagnosis of AA. This case of atypical, secondary CML was refractory to treatment with interferon a and hydroxyurea.

引用

页码：193 / +

页数：8

共 25 条

[1]

ADLER KR, 1978, CANCER, V41, P2206, DOI 10.1002/1097-0142(197806)41:6<2206::AID-CNCR2820410620>3.0.CO

[2]

2-0

[3] Therapy-related chronic myeloid leukemia: An epidemiological, clinical and pathogenetic appraisal [J].