Aggression and polymorphisms in AR, DAT1, DRD2, and COMT genes in Datoga pastoralists of Tanzania

被引：20

作者：

Butovskaya, Marina L. ^{[1
]}

Vasilyev, Vasiliy A. ^{[2
]}

Lazebny, Oleg E. ^{[3
]}

Suchodolskaya, Evgenija M. ^{[2
]}

Shibalev, Dmitri V. ^{[2
]}

Kulikov, Alex M. ^{[3
]}

Karelin, Dmitri V. ^{[4
]}

Burkova, Valentina N. ^{[1
]}

Mabulla, Audax ^{[5
]}

Ryskov, Alexey P. ^{[2
]}

机构：

[1] Russian Acad Sci, Inst Ethnol & Anthropol, Dept Cross Cultural Psychol & Human Ethol, Moscow 119991, Russia

[2] Russian Acad Sci, Inst Gene Biol, Dept Genome Org, Moscow 119334, Russia

[3] Russian Acad Sci, Koltsov Inst Dev Biol, Dept Genet, Moscow 119334, Russia

[4] Moscow MV Lomonosov State Univ, Fac Biol, Dept Ecol, Moscow 119991, Russia

[5] Univ Dar Es Salaam, Coll Arts & Social Sci, Dept Archaeol, Dar Es Salaam, Tanzania

来源：

SCIENTIFIC REPORTS | 2013年 / 3卷

关键词：

ANDROGEN RECEPTOR; SEROTONIN TRANSPORTER; SEX-DIFFERENCES; BEHAVIOR; DOPAMINE; PSYCHOGENETICS; DELINQUENCY; REPEATS; SYSTEM; LENGTH;

D O I：

10.1038/srep03148

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The aim of this study was to analyse the relationships between polymorphisms in four candidate genes (AR, DAT1, DRD2, and COMT) and aggression in men from a traditional society of East African pastoralists, the Datoga. Buss and Perry's Aggression Questionnaire was used to measure aggression. The number of CAG repeats in the AR gene was negatively correlated with physical aggression, anger, and hostility. Among the genes of the dopaminergic system, a significant single-gene effect was detected only for DRD2 with regard to anger. At the level of a two-gene model, a significant effect for DRD2 and a tendency for DAT1 were observed for the DAT1-DRD2 gene pair regarding hostility, and two tendencies were observed for the interaction effect of the DAT1-COMT pair regarding anger and hostility. These data suggest a probable link between physical aggression and direct fitness caused by strong sexual selection in Datoga men.

引用

页数：8

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