Non-alcoholic fatty liver disease in patients with psoriasis: therapeutic implications

被引：12

作者：

Klujszo, Elzbieta H. ^{[1
]}

Parcheta, Piotr ^{[1
]}

Witkowska, Anna B. ^{[2
]}

Krecisz, Beata ^{[3
]}

机构：

[1] Reg Hosp, Dept Dermatol, 7 Radiowa St, PL-25375 Kielce, Poland

[2] Grad Med Univ, Szeged, Hungary

[3] Jan Kochanowski Univ, Fac Med & Hlth Sci, Kielce, Poland

来源：

POSTEPY DERMATOLOGII I ALERGOLOGII | 2020年 / 37卷 / 04期

关键词：

psoriasis; liver disease; methotrexate; biologic agents; CARDIOVASCULAR-DISEASE; AMERICAN ASSOCIATION; PHYSICAL-ACTIVITY; METHOTREXATE; MODERATE; PATHOGENESIS; METAANALYSIS; DIAGNOSIS; ARTHRITIS; INJURY;

D O I：

10.5114/ada.2019.83983

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Non-alcoholic fatty liver disease (NAFLD) is the most common liver pathology in the western countries. Psoriatic patients are at higher risk of having NAFLD, and at higher risk of experiencing a more severe form of the disease with poorer outcomes. The components of the metabolic syndrome - obesity, lipid abnormalities, hypertension, and type 2 diabetes - significantly correlate with NAFLD progression. The inflammatory state present in psoriasis plays a significant role in development of NAFLD and the metabolic syndrome. All patients with psoriasis and insulin resistance and risk factors for metabolic syndrome should also been screened for NAFLD, and planning of the treatment options should always take into consideration the possible risks related to the liver, especially in patients with NAFLD.

引用

页码：468 / 474

页数：7

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