Bis-coumarin Derivatives and their Biological Activities

被引：90

作者：

Ren, Qing-Cheng ^{[1
]}

Gao, Chuan ^{[1
]}

Xu, Zhi ^{[1
]}

Feng, Lian-Shun ^{[1
]}

Liu, Ming-Liang ^{[2
,3
,4
]}

Wu, Xiang ^{[1
]}

Zhao, Feng ^{[1
]}

机构：

[1] WuXi AppTec, Wuhan, Hubei, Peoples R China

[2] Wuhan Univ Technol, Int Sch Mat Sci & Engn, Key Lab Adv Technol Mat Synth & Proc, Wuhan, Hubei, Peoples R China

[3] Chinese Acad Med Sci, Inst Med Biotechnol, Beijing 100050, Peoples R China

[4] Peking Union Med Coll, Beijing 100050, Peoples R China

来源：

CURRENT TOPICS IN MEDICINAL CHEMISTRY | 2018年 / 18卷 / 02期

关键词：

Bis-coumarin; anti-bacterial; antitumor; antiviral; hybrid compounds; structure-activity relationships; HIV-1 INTEGRASE INHIBITION; BISCOUMARIN DERIVATIVES; MOLECULAR DOCKING; IN-VITRO; CRYSTAL-STRUCTURE; DIHYDROPYRAN DERIVATIVES; ANTIINFLAMMATORY ACTIVITY; ANTIBACTERIAL ACTIVITIES; ANTITUMOR ACTIVITIES; MANNICH-BASES;

D O I：

10.2174/1568026618666180221114515

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Bis-coumarins have caused great interests in the recent years. These compounds exhibit diverse biological activities which are ascribed to their ability to exert noncovalent interactions with the various active sites in organisms. Some of them such as dicoumarolum and dicoumarol were approved for therapeutic purposes in clinical practice. Encouraged by the above facts, numerous bis-coumarin derivatives have been synthesized and screened for their biological activities, and many of them showed promising potency. This review is focused on the biological potential of bis-coumarin derivatives with particular mention of those exhibiting antibacterial, anticoagulant, anti-inflammatory, antiviral, anti-parasite and antitumor activities, and their structure-activity relationships are also discussed.

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页码：101 / 113

页数：13

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