Pathophysiology and Therapeutic Perspectives for Chemotherapy-induced Peripheral Neuropathy

被引：18

作者：

Avallone, Antonio ^{[1
]}

Bimonte, Sabrina ^{[2
,3
]}

Cardone, Claudia ^{[1
]}

Cascella, Macro ^{[2
]}

Cuomo, Arturo ^{[2
]}

机构：

[1] Ist Nazl Tumori IRCCS Fdn Pascale, Abdominal Oncol Div, Naples, Italy

[2] Ist Nazl Tumori IRCCS Fdn Pascale, Div Anesthesia & Pain Med, Naples, Italy

[3] Nazl Tumori IRCCS Fdn Pascale, Pain Med Ist, Div Anesthesia, I-80131 Naples, Italy

来源：

ANTICANCER RESEARCH | 2022年 / 42卷 / 10期

关键词：

Chemotherapy-induced peripheral neuropathy; pain management; target therapy; immunotherapy; INDUCED PAINFUL NEUROPATHY; CAPSAICIN 8-PERCENT PATCH; TAXANE-INDUCED NEUROPATHY; DORSAL-ROOT GANGLION; RANDOMIZED PHASE-II; DOUBLE-BLIND; OXIDATIVE STRESS; SIGMA-1; RECEPTOR; OVARIAN-CANCER; IN-VIVO;

D O I：

10.21873/anticanres.15971

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Chemotherapy-induced peripheral neuropathy (CIPN) develops as a challenging nerve-damaging adverse effect of anticancer drugs used in chemotherapy. The disorder may require a chemotherapy dose reduction and a cessation of administration of chemotherapeutic drugs. Its principal sensory symptoms include, tingling, and numbness in the hands and feet. Severe pain can be encompassed among clinical manifestations. CIPN affects dramatically the patient's quality of life (QoL). Pain and sensory symptoms may occur for months, or even years after the termination of chemotherapeutic drugs. Although many pharmacological and non-pharmacological therapeutic approaches have been tested to overcome these symptoms, there is currently no standardized treatment for CIPN. According to current guidelines, Duloxetine is the only recommended agent for painful neuropathic symptoms. Therefore, finding effective therapies for CIPN is mandatory. The aim of this review was to dissect CIPN, the target and immunotherapy-based approaches to this disorder, as well as to offer new insights for new therapeutic perspectives.

引用

页码：4667 / 4678

页数：12

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