Naive and memory CD4+ T cell survival controlled by clonal abundance

被引：290

作者：

Hataye, J ^{[1
]}

Moon, JJ

Khoruts, A

Reilly, C

Jenkins, MK

机构：

[1] Univ Minnesota, Sch Med, Ctr Immunol, Dept Microbiol, Minneapolis, MN 55455 USA

[2] Univ Minnesota, Sch Med, Ctr Immunol, Dept Med, Minneapolis, MN 55455 USA

[3] Univ Minnesota, Sch Publ Hlth, Div Biostat, Minneapolis, MN 55455 USA

来源：

SCIENCE | 2006年 / 312卷 / 5770期

关键词：

D O I：

10.1126/science.1124228

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Immunity to a plethora of microbes depends on a diverse repertoire of naive lymphocytes and the production of long-lived memory cells. We present evidence here that low clonal abundance in a polyclonal repertoire favors the survival and activation of naive CD4(+) T cells as well as the survival of their memory cell progeny. The inverse relation between clonal frequency and survival suggests that intraclonal competition could help maintain an optimally diverse repertoire of T cells and an optimal environment for the generation of long-lived memory cells.

引用

页码：114 / 116

页数：3

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