Aging in the circadian system: Considerations for health, disease prevention and longevity

被引：101

作者：

Gibson, Erin M. ^{[1
]}

Williams, Wilbur P., III ^{[1
]}

Kriegsfeld, Lance J. ^{[1
,2
]}

机构：

[1] Univ Calif Berkeley, Dept Psychol, Berkeley, CA 94720 USA

[2] Univ Calif Berkeley, Helen Wills Neurosci Inst, Berkeley, CA 94720 USA

来源：

EXPERIMENTAL GERONTOLOGY | 2009年 / 44卷 / 1-2期

关键词：

Senescence; Clock gene; CCG; Estrus; Ovulation; VASOACTIVE INTESTINAL POLYPEPTIDE; EARLY GENE-EXPRESSION; AGE-RELATED-CHANGES; SUPRACHIASMATIC NUCLEUS; MESSENGER-RNA; N-ACETYLTRANSFERASE; SHIFT WORK; NON-CONE; NON-ROD; MELANOPSIN;

D O I：

10.1016/j.exger.2008.05.007

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

The circadian system orchestrates internal physiology on a daily schedule to promote optimal health and maximize disease prevention. Chronic disruptions in circadian function are associated with an increase in a variety of disease states including, heart disease, ulcers and diabetes. With advanced age, the genes regulating circadian function at the cellular level become disorganized and the ability of the brain clock to entrain to local time diminishes. As a result, aged individuals exhibit a loss of temporal coordination among bodily systems, leading to deficits in homeostasis and sub-optimal functioning. Such disruptions in the circadian system appear to accelerate the aging process and contribute to senescence, with some systems being more vulnerable than others. This review explores aging-associated changes in circadian function and examines evidence linking such alterations to adverse health consequences in late life and promotion of the aging process. (c) 2008 Elsevier Inc. All rights reserved.

引用

页码：51 / 56

页数：6

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