GENETIC VARIATION IN HIF SIGNALING UNDERLIES QUANTITATIVE VARIATION IN PHYSIOLOGICAL AND LIFE-HISTORY TRAITS WITHIN LOWLAND BUTTERFLY POPULATIONS

被引:37
作者
Marden, James H. [1 ]
Fescemyer, Howard W. [1 ]
Schilder, Rudolf J. [1 ]
Doerfler, William R. [1 ]
Vera, Juan C. [1 ]
Wheat, Christopher W. [2 ]
机构
[1] Penn State Univ, Dept Biol, Mueller Lab 208, University Pk, PA 16802 USA
[2] Univ Helsinki, Dept Biosci, FIN-00014 Helsinki, Finland
基金
美国国家科学基金会; 芬兰科学院;
关键词
Adaptation; development; genetic variation; life-history evolution; physiology; polymorphism; DROSOPHILA-MELANOGASTER; HIGH-ALTITUDE; HEREDITARY PARAGANGLIOMA; PROLYL HYDROXYLASE; MELITAEA-CINXIA; DISPERSAL RATE; COMPLEX-II; BODY-SIZE; HYPOXIA; OXYGEN;
D O I
10.1111/evo.12004
中图分类号
Q14 [生态学(生物生态学)];
学科分类号
071012 ; 0713 ;
摘要
Oxygen conductance to the tissues determines aerobic metabolic performance in most eukaryotes but has cost/benefit tradeoffs. Here we examine in lowland populations of a butterfly a genetic polymorphism affecting oxygen conductance via the hypoxia-inducible factor (HIF) pathway, which senses intracellular oxygen and controls the development of oxygen delivery networks. Genetically distinct clades of Glanville fritillary (Melitaea cinxia) across a continental scale maintain, at intermediate frequencies, alleles in a metabolic enzyme (succinate dehydrogenase, SDH) that regulates HIF-1. One Sdhd allele was associated with reduced SDH activity rate, twofold greater cross-sectional area of tracheoles in flight muscle, and better flight performance. Butterflies with less tracheal development had greater post-flight hypoxia signaling, swollen & disrupted mitochondria, and accelerated aging of flight metabolic performance. Allelic associations with metabolic and aging phenotypes were replicated in samples from different clades. Experimentally elevated succinate in pupae increased the abundance of HIF-1 and expression of genes responsive to HIF activation, including tracheal morphogenesis genes. These results indicate that the hypoxia inducible pathway, even in lowland populations, can be an important axis for genetic variation underlying intraspecific differences in oxygen delivery, physiological performance, and life history.
引用
收藏
页码:1105 / 1115
页数:11
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