Enhanced podophyllotoxin production from Agrobacterium rhizogenes transformed cultures of Podophyllum hexandrum

被引：31

作者：

Giri, A

Giri, CC

Dhingra, V

Narasu, ML

机构：

[1] Jawaharlal Nehru Technol Univ, Ctr Biotechnol, Hyderabad 500028, Andhra Pradesh, India

[2] Osmania Univ, Dept Genet, Ctr Plant Mol Biol, Hyderabad 500007, Andhra Pradesh, India

来源：

NATURAL PRODUCT LETTERS | 2001年 / 15卷 / 04期

关键词：

Agrobacterium rhizogenes; Podophyllum hexandrum; podophyllotoxin; transformed cultures;

D O I：

10.1080/10575630108041286

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Podophyllotoxin, a potent chemotherapeutic agent is obtained from Podophyllum hexandrum Royle. Embryos of P. hexandrum were transformed using different strains of Agrobacterium rhizogenes viz. A(4), 15834, K-599. Transformed nature of them calli was ascertained and the cultures were further maintained as individual clones. HPLC analysis of transformed cultures depicted a three-fold increase in podophyllotoxin content in comparison to controls.

引用

页码：229 / 235

页数：7

共 10 条

[1] Production of podophyllotoxin from Podophyllum hexandrum:: a potential natural product for clinically useful anticancer drugs [J].