Sesquineolignans and Terpene-Sesquineolignans: Anti-Acetylcholinesterase Constituents from Illicium simonsii

被引：12

作者：

Dong, Chuanfu ^{[1
,2
]}

Liu, Lei ^{[1
,2
]}

Li, Xiaonian ^{[1
]}

Guan, Zhengye ^{[1
,2
]}

Luo, Huairong ^{[1
]}

Wang, Yifen ^{[1
]}

机构：

[1] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China

[2] Grad Univ Chinese Acad Sci, Beijing, Peoples R China

来源：

PLANTA MEDICA | 2013年 / 79卷 / 05期

关键词：

Illiciaceae; Illicium simonsii; sesquineolignans; terpene-sesquineolignans; anti-AChE activity; PRENYLATED C-6-C-3 COMPOUNDS; ACETYLCHOLINE; DERIVATIVES; BARK;

D O I：

10.1055/s-0032-1328287

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Chemical investigation of the aerial parts of Illicium simonsii resulted in the isolation of nine new compounds, simonsols A-E (1-5), simonsins A-B (7-8), terpene-sesquineolignans, clovane-dunnianol (9), and p-menthadunnianol (10). Compound 5 was equilibrated with 7 as an inseparable mixture. The structures were elucidated by extensive NMR and MS analysis. Compounds 9, 10, and the mixture of 5 and 7 moderately inhibited acetylcholinesterase with IC50 values of 4.58 mu M, 6.55 mu M, and 10.34 mu M, respectively.

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收藏

页码：338 / 347

页数：10

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