An APRIL to remember: novel TNF ligands as therapeutic targets

被引：265

作者：

Dillon, SR

Gross, JA

Ansell, SM

Novak, AJ

机构：

[1] Zymogenet Inc, Dept Autoimmun & Inflammat, Seattle, WA 98102 USA

[2] Mayo Clin, Mayo Clin Coll Med, Div Hematol & Internal Med, Rochester, MN 55905 USA

来源：

NATURE REVIEWS DRUG DISCOVERY | 2006年 / 5卷 / 03期

关键词：

D O I：

10.1038/nrd1982

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Since their discovery in 1998, the two TNF family members APRIL and BLyS/BAFF have received increasing attention. In addition to regulating normal B-cell development and immune responses, these molecules might be crucial in a diverse set of diseases, including autoimmunity and cancer. Although more has been published about the general biology of BLyS/BAFF than that of APRIL, many recent articles have described novel APRIL biology. Here we focus on APRIL, exploring its normal and pathological functions, and comparing the therapeutic molecules currently under development that target BLyS/BAFF alone, or APRIL and BLyS/BAFF together.

引用

页码：235 / 246

页数：12

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