Prominin-1/CD133: Lipid Raft Association, Detergent Resistance, and Immunodetection

被引：21

作者：

Karbanova, Jana ^{[1
,2
]}

Lorico, Aurelio ^{[3
]}

Bornhaeuser, Martin ^{[2
,4
]}

Corbeil, Denis ^{[1
,2
]}

Fargeas, Christine A. ^{[1
]}

机构：

[1] Tech Univ Dresden, Biotechnol Ctr BIOTEC, Dresden, Germany

[2] Tech Univ Dresden, DFG Ctr Regenerat Therapies Dresden CRTD, Dresden, Germany

[3] Roseman Univ Hlth Sci, Coll Med, Dept Pathol, Las Vegas, NV USA

[4] Univ Hosp Carl Gustav Carus, Med Clin & Polyclin 1, Dresden, Germany

来源：

STEM CELLS TRANSLATIONAL MEDICINE | 2018年 / 7卷 / 02期

关键词：

STEM-CELL MARKER; POLYTOPIC MEMBRANE-PROTEIN; APICAL PLASMA-MEMBRANE; HEMATOPOIETIC STEM; EPITHELIAL-CELLS; NEURAL PROGENITORS; LUBROL WX; CD133; RELEASE; MICROVILLI;

D O I：

10.1002/sctm.17-0223

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

The cell surface antigen prominin-1 (alias CD133) has gained enormous interest in the past 2 decades and given rise to debates as to its utility as a biological stem and cancer stem cell marker. Important and yet often overlooked knowledge that is pertinent to its physiological function has been generated in other systems given its more general expression beyond primitive cells. This article briefly discusses the importance of particular biochemical features of CD133 with relation to its association with membrane microdomains (lipid rafts) and proper immunodetection. It also draws attention toward the adequate use of detergents and caveats that may apply to the interpretation of the results generated.

引用

页码：155 / 160

页数：6

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