Initiation of Angiogenesis in Atherosclerosis: Smooth Muscle Cells as Mediators of the Angiogenic Response to Atheroma Formation

被引:39
作者
Ho-Tin-Noe, Benoit
Michel, Jean-Baptiste
机构
[1] Hop Bichat Claude Bernard, AP HP, F-75018 Paris, France
[2] Univ Paris Diderot, INSERM, UMR698, F-75018 Paris, France
关键词
ENDOTHELIAL GROWTH-FACTOR; HUMAN CORONARY-ARTERIES; HUMAN CAROTID ARTERIES; INTRAPLAQUE HEMORRHAGE; INTIMAL NEOVASCULARIZATION; PLAQUE VULNERABILITY; FACTOR EXPRESSION; MAST-CELLS; IN-VIVO; MICROVESSELS;
D O I
10.1016/j.tcm.2012.05.007
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Neovascularization of atherosclerotic lesions favors their progression toward rupture. Despite this pathophysiological importance, data regarding the mechanism(s) initiating plaque neovascularization are scarce. Recent findings indicate that smooth muscle cells located underneath early aortic atheromatous lesions display a pro-angiogenic phenotype, and that lipid mediators derived from these lesions are potent inducers of this phenotypic change. Here, we discuss these new data suggesting that smooth muscle cells could be the central organizers of an angiogenic response initiated by the very first cause of the atheromatous disease, the accumulation and retention of lipids in the arterial wall. (Trends Cardiovasc Med 2011;21:183-187) (C) 2011 Elsevier Inc. All rights reserved.
引用
收藏
页码:183 / 187
页数:5
相关论文
共 45 条
[11]   MicroRNA-100 Regulates Neovascularization by Suppression of Mammalian Target of Rapamycin in Endothelial and Vascular Smooth Muscle Cells [J].
Grundmann, Sebastian ;
Hans, Felix P. ;
Kinniry, Sheena ;
Heinke, Jennifer ;
Helbing, Thomas ;
Bluhm, Franziska ;
Sluijter, Joost P. G. ;
Hoefer, Imo ;
Pasterkamp, Gerard ;
Bode, Christoph ;
Moser, Martin .
CIRCULATION, 2011, 123 (09) :999-1009
[12]   HYPEREMIA OF THE AORTIC-WALL IN ATHEROSCLEROTIC MONKEYS [J].
HEISTAD, DD ;
ARMSTRONG, ML ;
MARCUS, ML .
CIRCULATION RESEARCH, 1981, 48 (05) :669-675
[13]   Composition of Carotid Atherosclerotic Plaque Is Associated With Cardiovascular Outcome A Prognostic Study [J].
Hellings, Willem E. ;
Peeters, Wouter ;
Moll, Frans L. ;
Piers, Sebastiaan R. D. ;
van Setten, Jessica ;
Van der Spek, Peter J. ;
de Vries, Jean-Paul P. M. ;
Seldenrijk, Kees A. ;
De Bruin, Peter C. ;
Vink, Aryan ;
Velema, Evelyn ;
de Kleijn, Dominique P. V. ;
Pasterkamp, Gerard .
CIRCULATION, 2010, 121 (17) :1941-U111
[14]   Early Atheroma-Derived Agonists of Peroxisome Proliferator-Activated Receptor-γ Trigger Intramedial Angiogenesis in a Smooth Muscle Cell-Dependent Manner [J].
Ho-Tin-Noe, Benoit ;
Le Dall, Julien ;
Gomez, Delphine ;
Louedec, Liliane ;
Vranckx, Roger ;
El-Bouchtaoui, Morad ;
Legres, Luc ;
Meilhac, Olivier ;
Michel, Jean-Baptiste .
CIRCULATION RESEARCH, 2011, 109 (09) :1003-U67
[15]   Neovascularization in early atherosclerotic lesions of human carotid arteries: Its potential contribution to plaque development [J].
Jeziorska, M ;
Woolley, DE .
HUMAN PATHOLOGY, 1999, 30 (08) :919-925
[16]  
Jeziorska M, 1999, J PATHOL, V188, P189
[17]   Ligands of peroxisome proliferator-activated receptor-γ increase the generation of vascular endothelial growth factor in vascular smooth muscle cells and in macrophages [J].
Jozkowicz, A ;
Dulak, J ;
Piatkowska, E ;
Placha, W ;
Dembinska-Kiec, A .
ACTA BIOCHIMICA POLONICA, 2000, 47 (04) :1147-1157
[18]   Neovascularization in human coronary arteries with lesions of different severity [J].
Juan-Babot, JO ;
Martínez-González, J ;
Berrozpe, M ;
Badimon, L .
REVISTA ESPANOLA DE CARDIOLOGIA, 2003, 56 (10) :978-986
[19]   Mast cells accompany microvessels in human coronary atheromas: Implications for intimal neovascularization and hemorrhage [J].
Kaartinen, M ;
Penttila, A ;
Kaartinen, M .
ATHEROSCLEROSIS, 1996, 123 (1-2) :123-131
[20]   Intraplaque hemorrhage and progression of coronary atheroma [J].
Kolodgie, FD ;
Gold, HK ;
Burke, AP ;
Fowler, DR ;
Kruth, HS ;
Weber, DK ;
Farb, A ;
Guerrero, LJ ;
Hayase, M ;
Kutys, R ;
Narula, J ;
Finn, AV ;
Virmani, R .
NEW ENGLAND JOURNAL OF MEDICINE, 2003, 349 (24) :2316-2325