Clay nanoparticles for regenerative medicine and biomaterial design: A review of clay bioactivity

被引：193
作者：
Mousa, Mohamed [1 ]
Evans, Nicholas D. [1 ]
Oreffo, Richard O. C. [1 ]
Dawson, Jonathan I. [1 ]
机构：
[1] Univ Southampton, Inst Dev Sci, Ctr Human Dev Stem Cells & Regenerat, Bone & Joint Res Grp, Southampton SO16 6YD, Hants, England
来源：
BIOMATERIALS | 2018年 / 159卷
基金：
英国工程与自然科学研究理事会; 英国生物技术与生命科学研究理事会;
关键词：
Clay nanoparticles; Nanocomposites; Stem cells; Cytotoxicity; Bioactivity; Cell differentiation; MESENCHYMAL STEM-CELLS; DOUBLE HYDROXIDE NANOPARTICLES; IN-VITRO BIOCOMPATIBILITY; HUMAN-ENDOTHELIAL-CELLS; DRUG-DELIVERY SYSTEMS; CROSS-LINKED PEO; OSTEOGENIC DIFFERENTIATION; NANOCOMPOSITE HYDROGELS; COMPOSITE SCAFFOLDS; CLAY/POLYMER NANOCOMPOSITES;
D O I：
10.1016/j.biomaterials.2017.12.024
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
Clay nanoparticles, composites and hydrogels are emerging as a new class of biomaterial with exciting potential for tissue engineering and regenerative medicine applications. Clay particles have been extensively explored in polymeric nanocomposites for self-assembly and enhanced mechanical properties as well as for their potential as drug delivery modifiers. In recent years, a cluster of studies have explored cellular interactions with clay nanoparticles alone or in combination with polymeric matrices. These pioneering studies have suggested new and unforeseen utility for certain clays as bioactive additives able to enhance cellular functions including adhesion, proliferation and differentiation, most notably for osteogenesis. This review examines the recent literature describing the potential effects of clay-based nanomaterials on cell function and examines the potential role of key clay physicochemical properties in influencing such interactions and their exciting possibilities for regenerative medicine. (C) 2018 Elsevier Ltd. All rights reserved.
引用
收藏
页码：204 / 214
页数：11
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