Methylglyoxal comes of AGE

被引：146

作者：

Ramasamy, R ^{[1
]}

Yan, SF ^{[1
]}

Schmidt, AM ^{[1
]}

机构：

[1] Columbia Univ, Med Ctr, Dept Surg, New York, NY 10032 USA

来源：

CELL | 2006年 / 124卷 / 02期

关键词：

D O I：

10.1016/j.cell.2006.01.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The posttranslational modification of proteins by methylglyoxal, a highly reactive compound derived from glycolysis, may contribute to aging, diabetes, and other disorders. In this issue of Cell, Brownlee and colleagues (Yao et al., 2006) demonstrate a specific mechanism by which methylglyoxal modifies a transcriptional corepressor to enhance gene expression.

引用

页码：258 / 260

页数：3

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