Fecal microbiota transplantation for fulminant Clostridium difficile infection in an allogeneic stem cell transplant patient

被引：87

作者：

Neemann, K. ^{[1
]}

Eichele, D. D.

Smith, P. W. ^{[1
]}

Bociek, R. ^{[2
]}

Akhtari, M. ^{[2
]}

Freifeld, A. ^{[1
]}

机构：

[1] Univ Nebraska Med Ctr, Div Infect Dis, Dept Internal Med, Omaha, NE 68198 USA

[2] Univ Nebraska Med Ctr, Sect Hematol Oncol, Dept Internal Med, Omaha, NE 68198 USA

来源：

TRANSPLANT INFECTIOUS DISEASE | 2012年 / 14卷 / 06期

关键词：

Clostridium difficile infection; fecal microbiota therapy; fecal transplant; RISK-FACTORS; DISEASE; RECIPIENTS; DIARRHEA; COLITIS; OUTCOMES; BACTERIOTHERAPY; EPIDEMIOLOGY; HOST;

D O I：

10.1111/tid.12017

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We present a case of severe Clostridium difficile infection (CDI) in a non-neutropenic allogeneic hematopoietic stem cell transplant recipient who was treated successfully with fecal microbiota therapy after standard pharmacologic therapy had failed. Following naso-jejunal instillation of donor stool, the patient's symptoms resolved within 48 h. Bowel resection was averted. This is the first case in the literature, to our knowledge, to describe fecal microbiota therapy in a profoundly immunocompromised host with severe CDI. We propose that fecal microbiota therapy be considered as a therapeutic option in immunosuppressed patients with refractory severe CDI.

引用

页码：E161 / E165

页数：5

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