Antiproliferative Activity of N-Substituted 2,4-Diamino-5-Aryl-5,6,7,8,9,10-Hexahydrobenzo[B][1,8]Naphthyridine-3-Carbonitriles

被引：4

作者：

Bardasov, I. N. ^{[1
]}

Alekseeva, A. Yu. ^{[1
]}

Ershov, O. V. ^{[1
]}

Mar'yasov, M. A. ^{[1
]}

机构：

[1] IN Ulyanov Chuvash State Univ, Cheboksary 428015, Chuvashia, Russia

来源：

PHARMACEUTICAL CHEMISTRY JOURNAL | 2020年 / 54卷 / 05期

关键词：

1; 8-naphthyridines; carbonitriles; malononitrile dimer; antiproliferative activity; 7-SUBSTITUTED 1,4-DIHYDRO-4-OXO-1-(2-THIAZOLYL)-1,8-NAPHTHYRIDINE-3-CARBOXYLIC ACIDS; ANTITUMOR AGENTS; CYTOTOXICITY; DERIVATIVES; INHIBITION;

D O I：

10.1007/s11094-020-02236-5

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Th antiproliferative activity ofN-substituted 2,4-diamino-5-aryl-5,6,7,8,9,10-hexahydrobenzo[b][1,8]naphthyridine-3-carbonitriles was studied. Substituents in the 5- and 7-positions of the naphthyridine ring had strong influences on the activity; in the 1-position, weak influences. Compounds with a C-5 3,4,5-trimethoxyphenyl radical were significantly superior to other derivatives. The influences of other substituents were not precisely established; however, a C-7 substituent played a key role in the manifestation of biological activity.

引用

页码：459 / 461

页数：3

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