Synaptic consolidation: an approach to long-term learning

被引：42
作者：
Clopath, Claudia [1 ]
机构：
[1] Univ Paris 05, Paris, France
来源：
COGNITIVE NEURODYNAMICS | 2012年 / 6卷 / 03期
关键词：
Synaptic tagging; Synaptic consolidation; Synaptic plasticity; Model; Behavior; Electrophysiology; Review; LATE-ASSOCIATIVITY; HIPPOCAMPAL CA1; MEMORY; POTENTIATION; LTP; INDUCTION; SPIKES; MODEL; MAINTENANCE; DEPRESSION;
D O I：
10.1007/s11571-011-9177-6
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Synaptic plasticity is thought to be the basis of learning and memory, but it is mostly studied on the timescale of mere minutes. This review discusses synaptic consolidation, a process that enables synapses to retain their strength for a much longer time (days to years), instead of returning to their original value. The process involves specific plasticity-related proteins, and depends on the dopamine D1/D5 receptors. Here, we review the research on synaptic consolidation, describing electrophysiology experiments, recent modeling work, as well as behavioral correlates.
引用
收藏
页码：251 / 257
页数：7
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