Metabolomic Profiling for the Identification of Novel Biomarkers and Mechanisms Related to Common Cardiovascular Diseas Form and Functiones

被引:301
作者
Shah, Svati H. [1 ,2 ,4 ]
Kraus, William E. [1 ,2 ]
Newgard, Christopher B. [1 ,3 ,5 ]
机构
[1] Duke Univ, Med Ctr, Sarah W Stedman Nutr & Metab Ctr, Durham, NC 27704 USA
[2] Duke Univ, Med Ctr, Div Cardiol, Durham, NC 27704 USA
[3] Duke Univ, Med Ctr, Div Endocrinol Metab & Nutr, Durham, NC 27704 USA
[4] Duke Univ, Med Ctr, Dept Med, Ctr Human Genet, Durham, NC 27704 USA
[5] Duke Univ, Med Ctr, Dept Pharmacol & Canc Biol, Durham, NC 27704 USA
基金
美国国家卫生研究院;
关键词
CORONARY-ARTERY-DISEASE; COLLABORATIVE CROSS; INSULIN-RESISTANCE; SYSTEMS GENETICS; RISK; REVEALS; MARKERS; INTENSITY; RESOURCE; PROTEIN;
D O I
10.1161/CIRCULATIONAHA.111.060368
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
[No abstract available]
引用
收藏
页码:1110 / 1120
页数:11
相关论文
共 53 条
[11]   A common variant on chromosome 9p21 affects the risk of myocardial infarction [J].
Helgadottir, Anna ;
Thorleifsson, Gudmar ;
Manolescu, Andrei ;
Gretarsdottir, Solveig ;
Blondal, Thorarinn ;
Jonasdottir, Aslaug ;
Jonasdottir, Adalbjorg ;
Sigurdsson, Asgeir ;
Baker, Adam ;
Palsson, Arnar ;
Masson, Gisli ;
Gudbjartsson, Daniel F. ;
Magnusson, Kristinn P. ;
Andersen, Karl ;
Levey, Allan I. ;
Backman, Valgerdur M. ;
Matthiasdottir, Sigurborg ;
Jonsdottir, Thorbjorg ;
Palsson, Stefan ;
Einarsdottir, Helga ;
Gunnarsdottir, Steinunn ;
Gylfason, Arnaldur ;
Vaccarino, Viola ;
Hooper, W. Craig ;
Reilly, Muredach P. ;
Granger, Christopher B. ;
Austin, Harland ;
Rader, Daniel J. ;
Shah, Svati H. ;
Quyyumi, Arshed A. ;
Gulcher, Jeffrey R. ;
Thorgeirsson, Gudmundur ;
Thorsteinsdottir, Unnur ;
Kong, Augustine ;
Stefansson, Kari .
SCIENCE, 2007, 316 (5830) :1491-1493
[12]   Effect of the volume and intensity of exercise training on insulin sensitivity [J].
Houmard, JA ;
Tanner, CJ ;
Slentz, CA ;
Duscha, BD ;
McCartney, JS ;
Kraus, WE .
JOURNAL OF APPLIED PHYSIOLOGY, 2004, 96 (01) :101-106
[13]   Exercise-Induced Changes in Metabolic Intermediates, Hormones, and Inflammatory Markers Associated With Improvements in Insulin Sensitivity [J].
Huffman, Kim M. ;
Slentz, Cris A. ;
Bateman, Lori A. ;
Thompson, Dana ;
Muehlbauer, Michael J. ;
Bain, James R. ;
Stevens, Robert D. ;
Wenner, Brett R. ;
Kraus, Virginia Byers ;
Newgard, Christopher B. ;
Kraus, William E. .
DIABETES CARE, 2011, 34 (01) :174-176
[14]   Relationships Between Circulating Metabolic Intermediates and Insulin Action in Overweight to Obese, Inactive Men and Women [J].
Huffman, Kim M. ;
Shah, Svati H. ;
Stevens, Robert D. ;
Bain, James R. ;
Muehlbauer, Michael ;
Slentz, Cris A. ;
Tanner, Charles J. ;
Kuchibhatla, Maragatha ;
Houmard, Joseph A. ;
Newgard, Christopher B. ;
Kraus, William E. .
DIABETES CARE, 2009, 32 (09) :1678-1683
[15]   A genome-wide perspective of genetic variation in human metabolism [J].
Illig, Thomas ;
Gieger, Christian ;
Zhai, Guangju ;
Roemisch-Margl, Werner ;
Wang-Sattler, Rui ;
Prehn, Cornelia ;
Altmaier, Elisabeth ;
Kastenmueller, Gabi ;
Kato, Bernet S. ;
Mewes, Hans-Werner ;
Meitinger, Thomas ;
de Angelis, Martin Hrabe ;
Kronenberg, Florian ;
Soranzo, Nicole ;
Wichmann, H-Erich ;
Spector, Tim D. ;
Adamski, Jerzy ;
Suhre, Karsten .
NATURE GENETICS, 2010, 42 (02) :137-U66
[16]   The Collaborative Cross, developing a resource for mammalian systems genetics: A status report of the Wellcome Trust cohort [J].
Iraqi, Fuad A. ;
Churchill, Gary ;
Mott, Richard .
MAMMALIAN GENOME, 2008, 19 (06) :379-381
[17]   Asymmetric and symmetric dimethylarginines are of similar predictive value for cardiovascular risk in the general population [J].
Kiechl, Stefan ;
Lee, Terry ;
Santer, Peter ;
Thompson, Graham ;
Tsimikas, Sotirios ;
Egger, Georg ;
Holt, David W. ;
Willeit, Johann ;
Xu, Qingbo ;
Mayr, Manuel .
ATHEROSCLEROSIS, 2009, 205 (01) :261-265
[18]   FiehnLib: Mass Spectral and Retention Index Libraries for Metabolomics Based on Quadrupole and Time-of-Flight Gas Chromatography/Mass Spectrometry [J].
Kind, Tobias ;
Wohlgemuth, Gert ;
Lee, Do Yup ;
Lu, Yun ;
Palazoglu, Mine ;
Shahbaz, Sevini ;
Fiehn, Oliver .
ANALYTICAL CHEMISTRY, 2009, 81 (24) :10038-10048
[19]   Proton NMR analysis of plasma is a weak predictor of coronary artery disease [J].
Kirschenlohr, Heide L. ;
Griffin, Julian L. ;
Clarke, Sarah C. ;
Rhydwen, Ranyl ;
Grace, Andrew A. ;
Schofield, Peter M. ;
Brindle, Kevin M. ;
Metcalfe, James C. .
NATURE MEDICINE, 2006, 12 (06) :705-710
[20]   Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance [J].
Koves, Timothy R. ;
Ussher, John R. ;
Noland, Robert C. ;
Slentz, Dorothy ;
Mosedale, Merrie ;
Ilkayeva, Olga ;
Bain, James ;
Stevens, Robert ;
Dyck, Jason R. B. ;
Newgard, Christopher B. ;
Lopaschuk, Gary D. ;
Muoio, Deborah M. .
CELL METABOLISM, 2008, 7 (01) :45-56