Characterization of a Novel HIV-1 CRF01_AE/CRF07_BC Recombinant Strain Among Men Who Have Sex with Men in Liaoning, China

被引：0
作者：
He, Shan [1 ,2 ,3 ]
Gao, Yang [1 ,2 ,3 ]
An, Minghui [1 ,2 ,3 ]
Zhao, Bin [1 ,2 ,3 ]
Wang, Lin [1 ,2 ,3 ]
Ding, Haibo [1 ,2 ,3 ]
Han, Xiaoxu [1 ,2 ,3 ]
机构：
[1] China Med Univ, Affiliated Hosp 1, Natl Clin Res Ctr Lab Med, NHC Key Lab AIDS Immunol, Shenyang 110001, Peoples R China
[2] Chinese Acad Med Sci, Key Lab AIDS Immunol, Shenyang, Peoples R China
[3] Key Lab AIDS Immunol Liaoning Prov, Shenyang, Peoples R China
来源：
AIDS RESEARCH AND HUMAN RETROVIRUSES | 2021年 / 37卷 / 01期
关键词：
HIV-1; CRF01_AE; CRF07_BC; unique recombinant form; EXPANDING EPIDEMIC; CRF01-AE; HISTORY;
D O I：
10.1089/aid.2020.0223
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
CRF01_AE and CRF07_BC are two widespread human immunodeficiency virus type 1 (HIV-1) strains among different high-risk populations, including men who have sex with men (MSM), in China. This co-epidemic of various HIV strains enables the production of second-generation recombinants. In this study, we detected a novel HIV-1 CRF01_AE/CRF07_BC recombinant from LN321945, an MSM lived in Liaoning province, northeast China. The phylogenetic and recombination analyses indicated the near full-length genome (NFLG) sequence of LN321945 had six recombination breakpoints, with three CRF07_BC fragments inserted into a CRF01_AE backbone. Further subregion trees analysis revealed that both CRF01_AE and CRF07_BC fragments were derived from two predominant HIV-1 strains among MSM. In addition, the NFLG of LN321945 was revealed to be clustered closely to another CRF01_AE/CRF07_BC recombinant previously identified in Shaanxi province, northwest China, but these two recombinants had distinct recombination structure and origin of CRF01_AE fragments. Hence, this study identified a second-generation recombinant between the main strains circulating among MSM, indicating more complicated trend of HIV-1 epidemic in China.
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页码：70 / 74
页数：5
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