Circulating MicroRNAs as Novel Biomarkers for the Early Diagnosis of Acute Coronary Syndrome

被引：60

作者：

Deddens, J. C. ^{[1
]}

Colijn, J. M. ^{[1
]}

Oerlemans, M. I. F. J. ^{[1
]}

Pasterkamp, G. ^{[1
]}

Chamuleau, S. A. ^{[1
]}

Doevendans, P. A. ^{[1
,2
]}

Sluijter, J. P. G. ^{[1
,2
]}

机构：

[1] Univ Med Ctr Utrecht, Dept Cardiol, Div Heart & Lungs, NL-3584 CX Utrecht, Netherlands

[2] Netherlands Heart Inst ICIN, Utrecht, Netherlands

来源：

JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH | 2013年 / 6卷 / 06期

关键词：

ACS; Circulating microRNAs; Myocardial infarction; Biomarkers; ACUTE MYOCARDIAL-INFARCTION; MUSCLE-SPECIFIC MICRORNA; ACID-BINDING PROTEIN; CARDIAC TROPONIN-I; SENSITIVE BIOMARKERS; PERIPHERAL-BLOOD; PLASMA MICRORNA; MESSENGER-RNAS; HEART-DISEASE; CK-MB;

D O I：

10.1007/s12265-013-9493-9

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Small non-coding microRNAs (miRNAs) are important physiological regulators of post-transcriptional gene expression. miRNAs not only reside in the cytoplasm but are also stably present in several extracellular compartments, including the circulation. For that reason, miRNAs are proposed as diagnostic biomarkers for various diseases. Early diagnosis of acute coronary syndrome (ACS), especially non-ST elevated myocardial infarction and unstable angina pectoris, is essential for optimal treatment outcome, and due to the ongoing need for additional identifiers, miRNAs are of special interest as biomarkers for ACS. This review highlights the nature and cellular release mechanisms of circulating miRNAs and therefore their potential role in the diagnosis of myocardial infarction. We will give an update of clinical studies addressing the role of circulating miRNA expression after myocardial infarction and explore the diagnostic value of this potential biomarker.

引用

页码：884 / 898

页数：15

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