Synthesis, crystal structures, molecular docking and urease inhibition studies of Ni(II) and Cu(II) Schiff base complexes

被引：27

作者：

Sangeeta, S. ^{[1
]}

Ahmad, K. ^{[1
]}

Noorussabah, N. ^{[1
]}

Bharti, S. ^{[1
]}

Mishra, M. K. ^{[1
]}

Sharma, S. R. ^{[1
]}

Choudhary, M. ^{[1
]}

机构：

[1] Natl Inst Technol Patna, Dept Chem, Patna 800005, Bihar, India

来源：

JOURNAL OF MOLECULAR STRUCTURE | 2018年 / 1156卷

关键词：

Schiff base; Thermal analysis; Molecular docking; Urease inhibitor; DIMERIC COPPER(II) COMPLEXES; TRANSITION-METAL-COMPLEXES; JACK-BEAN UREASE; NICKEL(II) COMPLEXES; LIGAND; DERIVATIVES; BINDING; ACID; FLUORESCENCE; COBALT(II);

D O I：

10.1016/j.molstruc.2017.11.062

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

[NUM 1 and [Cu(L)(2)](2) [HL = 2-((E)-(2-methoxyphenylimino)methyl)-4,6-dichlorophenol] Schiff base complexes have been successfully synthesized and were characterized by FT-IR, UV-Vis, fluorescence spectroscopy and thermogravimetric analysis. The crystal structures of the two complexes were determined through X-ray crystallography. Its inhibitory activity against Helicobacter pylori urease was evaluated in vitro and showed strong inhibitory activity against H. pylori urease compared with acetohydroxamic acid (IC50 = 42.12 mu molL(-1)), which is a positive reference. A docking analysis using the AutoDock 4.0 program could explain the inhibitory activity of the complex against urease. (C) 2017 Elsevier B.V. All rights reserved.

引用

页码：1 / 11

页数：11

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