γδ T cells and NK cells - distinct pathogenic roles as innate-like immune cells in CNS autoimmunity

被引：10

作者：

Edwards, Sarah C. ^{[1
]}

McGinley, Aoife M. ^{[1
]}

McGuinness, Niamh C. ^{[1
,2
]}

Mills, Kingston H. G. ^{[1
]}

机构：

[1] Univ Dublin Trinity Coll, Sch Biochem & Immunol, Trinity Biomed Sci Inst, Immune Regulat Res Grp, Dublin 2, Ireland

[2] Univ Dublin Trinity Coll, Inst Neurosci, Dublin 2, Ireland

来源：

FRONTIERS IN IMMUNOLOGY | 2015年 / 6卷

基金：

爱尔兰科学基金会;

关键词：

gamma delta T cells; NK cells; IL-17; multiple sclerosis; experimental autoimmune encephalomyelitis; autoimmunity; NATURAL-KILLER-CELLS; EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS; CENTRAL-NERVOUS-SYSTEM; MULTIPLE-SCLEROSIS; PERIPHERAL-BLOOD; IFN-GAMMA; CEREBROSPINAL-FLUID; INTERFERON-GAMMA; TH17; CELLS; IN-VIVO;

D O I：

10.3389/fimmu.2015.00455

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

[No abstract available]

引用

页数：6

共 70 条

[1] Encephalitogenic T cells that stably express both T-bet and RORγt consistently produce IFNγ but have a spectrum of IL-17 profiles [J].

Abromson-Leeman, Sara ;

Bronson, Roderick T. ;

Dorf, Martin E. .

JOURNAL OF NEUROIMMUNOLOGY, 2009, 215 (1-2) :10-24

[2]

Asea A, 1998, IMMUNOLOGY, V93, P296

[3] Loss of T-bet, but not STAT1, prevents the development of experimental autoimmune encephalomyelitis [J].

Bettelli, E ;

Sullivan, B ;

Szabo, SJ ;

Sobel, RA ;

Glimcher, H ;

Kuchroo, VK .

JOURNAL OF EXPERIMENTAL MEDICINE, 2004, 200 (01) :79-87

[4] Regulatory CD56bright natural killer cells mediate immunomodulatory effects of IL-2Rα-targeted therapy (daclizumab) in multiple sclerosis [J].

Bielekova, B ;

Catalfamo, M ;

Reichert-Scrivner, S ;

Packer, A ;

Cerna, M ;

Waldmann, TA ;

McFarland, H ;

Henkart, PA ;

Martin, R .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (15) :5941-5946

[5]

BILLIAU A, 1988, J IMMUNOL, V140, P1506

[6] Risk of Natalizumab-Associated Progressive Multifocal Leukoencephalopathy [J].

Bloomgren, Gary ;

Richman, Sandra ;

Hotermans, Christophe ;

Subramanyam, Meena ;

Goelz, Susan ;

Natarajan, Amy ;

Lee, Sophia ;

Plavina, Tatiana ;

Scanlon, James V. ;

Sandrock, Alfred ;

Bozic, Carmen .

NEW ENGLAND JOURNAL OF MEDICINE, 2012, 366 (20) :1870-1880

[7] NK phenotypic markers and IL2 response in NK cells from elderly people [J].

Borrego, F ;

Alonso, MC ;

Galiani, MD ;

Carracedo, J ;

Ramirez, R ;

Ostos, B ;

Peña, J ;

Solana, R .

EXPERIMENTAL GERONTOLOGY, 1999, 34 (02) :253-265

[8] Pivotal Role of Dermal IL-17-Producing γδ T Cells in Skin Inflammation [J].

Cai, Yihua ;

Shen, Xiaoyan ;

Ding, Chuanlin ;

Qi, Chunjian ;

Li, Kejia ;

Li, Xia ;

Jala, Venkatakrishna R. ;

Zhang, Huang-ge ;

Wang, Tian ;

Zheng, Jie ;

Yan, Jun .

IMMUNITY, 2011, 35 (04) :596-610

[9] RORγt drives production of the cytokine GM-CSF in helper T cells, which is essential for the effector phase of autoimmune neuroinflammation [J].

Codarri, Laura ;

Gyuelveszi, Gabor ;

Tosevski, Vinko ;

Hesske, Lysann ;

Fontana, Adriano ;

Magnenat, Laurent ;

Suter, Tobias ;

Becher, Burkhard .

NATURE IMMUNOLOGY, 2011, 12 (06) :560-U248

[10] Oral-resident natural Th17 cells and γδ T cells control opportunistic Candida albicans infections [J].

Conti, Heather R. ;

Peterson, Alanna C. ;

Brane, Lucas ;

Huppler, Anna R. ;

Hernandez-Santos, Nydiaris ;

Whibley, Natasha ;

Garg, Abhishek V. ;

Simpson-Abelson, Michelle R. ;

Gibson, Gregory A. ;

Mamo, Anna J. ;

Osborne, Lisa C. ;

Bishu, Shrinivas ;

Ghilardi, Nico ;

Siebenlist, Ulrich ;

Watkins, Simon C. ;

Artis, David ;

McGeachy, Mandy J. ;

Gaffen, Sarah L. .

JOURNAL OF EXPERIMENTAL MEDICINE, 2014, 211 (10) :2075-2084

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