Systematic Review and Meta-analysis of Pharmacological Treatment of the Symptoms of Attention-Deficit/Hyperactivity Disorder in Children with Pervasive Developmental Disorders

被引：81

作者：

Reichow, Brian ^{[1
]}

Volkmar, Fred R. ^{[1
]}

Bloch, Michael H. ^{[1
]}

机构：

[1] Yale Univ, Sch Med, Ctr Child Study, New Haven, CT 06519 USA

来源：

JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS | 2013年 / 43卷 / 10期

基金：

美国国家卫生研究院;

关键词：

Autism; Pervasive developmental disorder; Attention deficit/hyperactivity disorder; Methylphenidate; Meta-analysis; Atomoxetine; Clonidine; ADHD; ASD; Autism spectrum disorder; PDD; PDD-NOS; DEFICIT HYPERACTIVITY DISORDER; AUTISM SPECTRUM DISORDERS; PSYCHIATRIC-DISORDERS; MEDICATION USE; ADOLESCENTS; METHYLPHENIDATE; ATOMOXETINE; EFFICACY; PLACEBO; PREVALENCE;

D O I：

10.1007/s10803-013-1793-z

中图分类号：

B844 [发展心理学（人类心理学）];

学科分类号：

040202 ;

摘要：

Many children with pervasive developmental disorders (PDD) exhibit behaviors and symptoms of attention-deficit/hyperactivity disorder (ADHD). We sought to determine the relative efficacy of medications for treating ADHD symptoms in children with PDD by identifying all double-blind, randomized, placebo-controlled trials examining the efficacy of medications for treating ADHD symptoms in children with PDD. We located seven trials involving 225 children. A random effects meta-analysis of four methylphenidate trials showed methylphenidate to be effective for treating ADHD symptoms in children with PDD (ES = .67). Several adverse events were greater for children were taking methylphenidate compared to placebo. An individual trial of clonidine and two trials of atomoxetine suggest these agents may also be effective in treating ADHD symptoms in children with PDD.

引用

页码：2435 / 2441

页数：7

共 41 条

[1]

Aman MG, 2005, ARCH GEN PSYCHIAT, V62, P1266

[2] Acute and long-term safety and tolerability of risperidone in children with autism [J].

Aman, MG ;

Arnold, LE ;

McDougle, CJ ;

Vitiello, B ;

Scahill, L ;

Davies, M ;

McCracken, JT ;

Tierney, E ;

Nash, PL ;

Posey, DJ ;

Chuang, S ;

Martin, A ;

Shah, B ;

Gonzalez, NM ;

Swiezy, NB ;

Ritz, L ;

Koenig, K ;

McGough, J ;

Ghuman, JK ;

Lindsay, RL .

JOURNAL OF CHILD AND ADOLESCENT PSYCHOPHARMACOLOGY, 2005, 15 (06) :869-884

[3]

[Anonymous], 2008, COCHRANE HDB SYSTEMA, DOI DOI 10.1002/9780470712184.FMATTER

[4]

[Anonymous], CMAJ

[5]

[Anonymous], COMPREHENSIVE METAAN

[6]

[Anonymous], 2000, DIAGN STAT MAN, V4th

[7] Atomoxetine for hyperactivity in autism spectrum disorders: Placebo-controlled crossover pilot trial [J].

Arnold, L. Eugene ;

Aman, Michael G. ;

Cook, Amelia M. ;

Witwer, Andrea N. ;

Hall, Kristy L. ;

Thompson, Susan ;

Ramadan, Yaser .

JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY, 2006, 45 (10) :1196-1205

[8] Efficacy and safety of atomoxetine for attention-deficit/hyperactivity disorder in children and adolescents-meta-analysis and meta-regression analysis [J].

Cheng, Jackie Y. W. ;

Chen, Ronald Y. L. ;

Ko, John S. N. ;

Ng, Emil M. L. .

PSYCHOPHARMACOLOGY, 2007, 194 (02) :197-209

[9]

Conners CK., 2001, Conner's Rating Scales-Revised (CSR-R) Technical Manual (includes auxilliary scales: CADS-P and CADS-T)

[10] A meta-analysis of clonidine for symptoms of attention-deficit hyperactivity disorder [J].

Connor, DF ;

Fletcher, KE ;

Swanson, JM .

JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY, 1999, 38 (12) :1551-1559

← 1 2 3 4 5 →