Single nucleotide polymorphisms typing of Mycobacterium leprae reveals focal transmission of leprosy in high endemic regions of India

被引：15

作者：

Lavania, M. ^{[1
]}

Jadhav, R. S. ^{[2
]}

Turankar, R. P. ^{[1
]}

Chaitanya, V. S. ^{[1
]}

Singh, M. ^{[3
]}

Sengupta, U. ^{[1
]}

机构：

[1] TLM Community Hosp, Stanley Browne Lab, Delhi 110093, India

[2] Govt Inst Sci, Dept Microbiol, Bombay, Maharashtra, India

[3] LRS Inst TB & Resp Dis, Delhi, India

来源：

CLINICAL MICROBIOLOGY AND INFECTION | 2013年 / 19卷 / 11期

关键词：

Delhi; Mycobacterium leprae; Purulia; single-nucleotide polymorphisms; transmission; SHORT TANDEM REPEATS; STRAINS; POPULATION; DIVERSITY;

D O I：

10.1111/1469-0691.12125

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Earlier studies indicate that genotyping of Mycobaterium leprae based on single-nucleotide polymorphisms (SNPs) is useful for analysis of the global spread of leprosy. In the present study, we investigated the diversity of M.leprae at eight SNP loci using 180 clinical isolates obtained from patients with leprosy residing mainly in Delhi and Purulia (West Bengal) regions. It was observed that the frequency of SNP type 1 and subtype D was most predominant in the Indian population. Further, the SNP type 2 subtype E was noted only from East Delhi region and SNP type 2 subtype G was noted only from the nearby areas of Hoogly district of West Bengal. These results indicate the occurrence of focal transmission of M.leprae infection and demonstrate that analysis by SNP typing has great potential to help researchers in understanding the transmission of M.leprae infection in the community.

引用

页码：1058 / 1062

页数：5

共 29 条

[1]

Anonomyous, 2011, WEEKLY EPIDEMIOLOGIC, V86, P389

[2]

[Anonymous], 2008, Wkly Epidemiol Rec, V83, P293

[3]

[Anonymous], 2003, Wkly Epidemiol Rec, V78, P9

[4]

[Anonymous], 2012, HARRISONS ONLINE

[5]

BLAKE LA, 1987, REV INFECT DIS, V9, P562

[6] Massive gene decay in the leprosy bacillus [J].

Cole, ST ;

Eiglmeier, K ;

Parkhill, J ;

James, KD ;

Thomson, NR ;

Wheeler, PR ;

Honoré, N ;

Garnier, T ;

Churcher, C ;

Harris, D ;

Mungall, K ;

Basham, D ;

Brown, D ;

Chillingworth, T ;

Connor, R ;

Davies, RM ;

Devlin, K ;

Duthoy, S ;

Feltwell, T ;

Fraser, A ;

Hamlin, N ;

Holroyd, S ;

Hornsby, T ;

Jagels, K ;

Lacroix, C ;

Maclean, J ;

Moule, S ;

Murphy, L ;

Oliver, K ;

Quail, MA ;

Rajandream, MA ;

Rutherford, KM ;

Rutter, S ;

Seeger, K ;

Simon, S ;

Simmonds, M ;

Skelton, J ;

Squares, R ;

Squares, S ;

Stevens, K ;

Taylor, K ;

Whitehead, S ;

Woodward, JR ;

Barrell, BG .

NATURE, 2001, 409 (6823) :1007-1011

[7] THE MYCOBACTERIUM-LEPRAE GENOME - SYSTEMATIC SEQUENCE-ANALYSIS IDENTIFIES KEY CATABOLIC ENZYMES, ATP-DEPENDENT TRANSPORT-SYSTEMS AND A NOVEL POLA LOCUS ASSOCIATED WITH GENOMIC VARIABILITY [J].

FSIHI, H ;

COLE, ST .

MOLECULAR MICROBIOLOGY, 1995, 16 (05) :909-919

[8]

Gillis T, 2009, LEPROSY REV, V80, P250

[9] Multiple polymorphic loci for molecular typing of strains of Mycobacterium leprae [J].

Groathouse, NA ;

Rivoire, B ;

Kim, H ;

Lee, H ;

Cho, SN ;

Brennan, PJ ;

Vissa, VD .

JOURNAL OF CLINICAL MICROBIOLOGY, 2004, 42 (04) :1666-1672

[10]

Izumi S, 1999, Int J Lepr Other Mycobact Dis, V67, pS67

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