Analysis of amino acids in autism spectrum disorders

被引：16

作者：

Zurawicz, Ewa ^{[1
]}

Kaluzna-Czaplinska, Joanna ^{[1
]}

机构：

[1] Lodz Univ Technol, Dept Chem, Inst Gen & Ecol Chem, PL-90924 Lodz, Poland

来源：

TRAC-TRENDS IN ANALYTICAL CHEMISTRY | 2015年 / 73卷

关键词：

Analytical method; Amino acid; Autism spectrum disorders; Biomarker; Chemometrics; Chromatography; Mass spectrometry; Magnetic resonance spectroscopy; GAS CHROMATOGRAPHY/MASS SPECTROMETRY; OXIDATIVE STRESS; RESONANCE-SPECTROSCOPY; METABOLITE ALTERATIONS; PRACTICE PARAMETER; HEALTHY-CHILDREN; URINE; BIOMARKERS; SERUM; TRYPTOPHAN;

D O I：

10.1016/j.trac.2015.04.029

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The relationship between comorbidities associated with amino acids (AAs) and autism spectrum disorder (ASD) is the subject of much research. The diagnosis of these co-occurring disorders based on measurements of levels of AAs in clinical samples poses a challenge. The development of a variety of analytical platforms, particularly chromatographic methods, mass spectrometry and magnetic resonance spectroscopy, together with chemometric statistical methods, enables sensitive detection of abnormalities related to AAs. We present the application of analytical methods to the study of Ms in ASD. Moreover, this review highlights the role of some AAs as potential biomarkers for ASD. (C) 2015 Elsevier B.V. All rights reserved.

引用

页码：91 / 118

页数：28

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