Androgen Receptor Signaling Fuels DNA Repair and Radioresistance in Prostate Cancer

被引：38

作者：

Bartek, Jiri ^{[1
,2
]}

Mistrik, Martin ^{[2
]}

Bartkova, Jirina ^{[1
]}

机构：

[1] Danish Canc Soc Res Ctr, DK-2100 Copenhagen, Denmark

[2] Palacky Univ, Inst Mol & Translat Med, Fac Med & Dent, CR-77147 Olomouc, Czech Republic

来源：

CANCER DISCOVERY | 2013年 / 3卷 / 11期

关键词：

DAMAGE;

D O I：

10.1158/2159-8290.CD-13-0679

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Successful treatment by genotoxic modalities including radiotherapy is commonly hampered by treatment resistance in advanced cancers. Two new studies now reveal that androgen receptor signaling transcriptionally upregulates a large subset of DNA repair genes, thereby enhancing the repair capacity and promoting radioresistance of prostate cancer. These results provide a mechanistic rationale for a combined treatment by ionizing radiation and androgen deprivation therapy. (C)2013 AACR.

引用

页码：1222 / 1224

页数：3

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