Masked Hypertension is Associated With Cognitive Decline in Geriatric Age-Geriatric MASked Hypertension and Cognition (G-MASH-cog) Study

被引:9
作者
Esme, Mert [1 ]
Yavuz, Burcu Balam [2 ]
Yavuz, Bunyamin [3 ]
Asil, Serkan [4 ]
Dogrul, Rana Tuna [2 ]
Sumer, Fatih [2 ]
Kilic, Mustafa Kemal [2 ]
Kizilarslanoglu, Muhammet Cemal [2 ]
Varan, Hacer Dogan [2 ]
Sagir, Aykut [2 ]
Balci, Cafer [2 ]
Halil, Meltem [2 ]
Cankurtaran, Mustafa [2 ]
机构
[1] Hacettepe Univ, Dept Internal Med, Fac Med, Ankara, Turkey
[2] Hacettepe Univ, Div Geriatr Med, Dept Internal Med, Fac Med, Ankara, Turkey
[3] Med Pk Hosp, Dept Cardiol, Ankara, Turkey
[4] Hacettepe Univ, Dept Cardiol, Fac Med, Ankara, Turkey
来源
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES | 2018年 / 73卷 / 02期
关键词
Masked hypertension; Cognitive functions; Geriatrics; AMBULATORY BLOOD-PRESSURE; ANTIHYPERTENSIVE TREATMENT; ALZHEIMERS-DISEASE; PROGNOSTIC VALUE; WHITE-COAT; PREVALENCE; DEMENTIA; INDIVIDUALS; POPULATION; IMPAIRMENT;
D O I
10.1093/gerona/glx150
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
Background: Masked hypertension is described as high ambulatory blood pressure measurements (ABPM) where office blood pressure measurements are normal. Effect of hypertension on cognitive functions is well known. However, the effect of masked hypertension on cognitive functions is unclear. The aim of this study is to examine the relationship between masked hypertension and cognitive functions. Methods: One hundred-two normotensive patients admitted to the Geriatric Medicine outpatient clinic were included. Exclusion criteria were hypertension, dementia, major depression, and usage of antihypertensive medication. All patients underwent ABPM procedures and average daytime blood pressure, mean blood pressure at night and the 24-hour average blood pressure measurements were recorded. Comprehensive geriatric assessment tests and neuropsychological tests were administered. The diagnosis of masked hypertension was based on the definitions in the 2013 guideline of the European Society of Cardiology. Results: Forty-four patients (43%) were diagnosed with masked hypertension. Patients with masked hypertension had significantly lower scores on Mini-Mental State Examination (MMSE) test, Quick Mild Cognitive Impairment Test (QMCI), and Categorical Fluency Test than the normotensive patients (p = .011; p = .046; and p = .004; respectively). Montreal Cognitive Assessment Scale test score was lower in masked hypertension, although this was not statistically significant. Conclusion: This study may indicate that geriatric patients with masked hypertension, compared to normotensive patients have decreased cognitive functions. Masked hypertension should be kept in mind while assessing older adults. When masked hypertension is detected, cognitive assessment is essential to diagnose possible cognitive dysfunction at early stage.
引用
收藏
页码:248 / 254
页数:7
相关论文
共 48 条
[1]   Pathogenesis and treatment of kidney disease and hypertension - Home blood pressure monitoring in CKD [J].
Andersen, MJ ;
Khawandi, W ;
Agarwal, R .
AMERICAN JOURNAL OF KIDNEY DISEASES, 2005, 45 (06) :994-1001
[2]  
[Anonymous], CARDIAC ARTERIAL TAR
[3]  
[Anonymous], J GERONTOL A
[4]   Validation of Katz index of independence in activities of daily living in Turkish older adults [J].
Arik, Gunes ;
Varan, Hacer Dogan ;
Yavuz, Burcu Balam ;
Karabulut, Erdem ;
Kara, Ozgur ;
Kilic, Mustafa Kemal ;
Kizilarslanoglu, Muhammet Cemal ;
Sumer, Fatih ;
Kuyumcu, Mehmet Emin ;
Yesil, Yusuf ;
Halil, Meltem ;
Cankurtaran, Mustafa .
ARCHIVES OF GERONTOLOGY AND GERIATRICS, 2015, 61 (03) :344-350
[5]  
Ates I, 2015, MED SCI MONITOR, V21, P1022, DOI 10.12659/MSM.892684
[6]   Impact of Ambulatory Blood Pressure Monitoring on Reclassification of Hypertension Prevalence and Control in Older People in Spain [J].
Banegas, Jose R. ;
de la Cruz, Juan J. ;
Graciani, Auxiliadora ;
Lopez-Garcia, Esther ;
Gijon-Conde, Teresa ;
Ruilope, Luis M. ;
Rodriguez-Artalejo, Fernando .
JOURNAL OF CLINICAL HYPERTENSION, 2015, 17 (06) :453-461
[7]   Cardiovascular prognosis of "masked hypertension" detected by blood pressure self-measurement in elderly treated hypertensive patients [J].
Bobrie, G ;
Chatellier, G ;
Genes, N ;
Clerson, P ;
Vaur, L ;
Vaisse, L ;
Menard, J ;
Mallion, JM .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2004, 291 (11) :1342-1349
[8]   Prognostic accuracy of day versus night ambulatory blood pressure:: a cohort study [J].
Boggia, Jose ;
Li, Yan ;
Thijs, Lutgarde ;
Hansen, Tine W. ;
Kikuya, Masahiro ;
Bjorklund-Bodegard, Kristina ;
Richart, Tom ;
Ohkuba, Tkayashi ;
Kuznetsova, Tatiana ;
Torp-Pedersen, Christian ;
Lind, Lars ;
Ibsen, Hans ;
Imaiji, Yutaka ;
Wang, Jiguang ;
Sandoya, Edgardp ;
O'Brien, Eoin ;
Staessen, Jan A. .
LANCET, 2007, 370 (9594) :1219-1229
[9]  
Brink T.L., 1982, CLIN GERONTOLOGIST, V1, P37, DOI DOI 10.1300/J018V01N0106
[10]   Assessment of endothelial function in Alzheimer's disease: Is Alzheimer's disease a vascular disease? [J].
Dede, Didem Sener ;
Yavuz, Bunyamin ;
Yavuz, Burcu Balam ;
Cankurtaran, Mustafa ;
Halil, Meltem ;
Ulger, Zekeriya ;
Cankurtaran, Eylem Sahin ;
Aytemir, Kudret ;
Kabakci, Giray ;
Ariogul, Servet .
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY, 2007, 55 (10) :1613-1617