Wnt signaling polarizes an early C-elegans blastomere to distinguish endoderm from mesoderm

被引：411

作者：

Thorpe, CJ ^{[1
]}

Schlesinger, A ^{[1
]}

Carter, JC ^{[1
]}

Bowerman, B ^{[1
]}

机构：

[1] UNIV OREGON,INST MOL BIOL,EUGENE,OR 97403

来源：

CELL | 1997年 / 90卷 / 04期

关键词：

D O I：

10.1016/S0092-8674(00)80530-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A polarizing signal induces endoderm production by a 4-cell stage blastomere in C. elegans called EMS. We identified 16 mutations in five genes, mom-1 through mom-5, required for EMS to produce endoderm. mom-1, mom-2, and mom-3 are required in the signaling cell, P-2, while mom-4 is required in EMS. P-2 signaling downregulates an HMG domain protein, POP-1, in one EMS daughter. The sequence of mom-2 predicts that it encodes a member of the Wnt family of secreted glycoproteins, which in other systems activate HMG domain proteins. Defective mitotic spindle orientations in mom mutant embryos indicate that Wnt signaling influences cytoskeletal polarity in blastomeres throughout the early embryo.

引用

页码：695 / 705

页数：11

共 43 条

[1] TRANSCRIPT ANALYSIS OF GLP-1 AND LIN-12, HOMOLOGOUS GENES REQUIRED FOR CELL-INTERACTIONS DURING DEVELOPMENT OF C-ELEGANS [J].