Antitrypanosomal Triterpenoid with an ε-Lactone E-Ring from Salvia urmiensis

被引：37

作者：

Farimani, Mahdi Moridi ^{[1
]}

Ebrahimi, Samad Nejad ^{[1
,2
]}

Salehi, Peyman ^{[1
]}

Bahadori, Mir Babak ^{[1
]}

Sonboli, Ali ^{[3
]}

Khayasi, Hamid Reza ^{[4
]}

Zimmermann, Stefanie ^{[2
,5
]}

Kaiser, Marcel ^{[5
,6
]}

Hamburger, Matthias ^{[2
]}

机构：

[1] Shahid Beheshti Univ, Med Plants & Drugs Res Inst, Dept Phytochem, GC, Tehran, Iran

[2] Univ Basel, Div Pharmaceut Biol, Dept Pharmaceut Sci, CH-4056 Basel, Switzerland

[3] Shahid Beheshti Univ, Med Plants & Drugs Res Inst, Dept Biol, GC, Tehran, Iran

[4] Shahid Beheshti Univ, Dept Chem, GC, Tehran, Iran

[5] Swiss Trop & Publ Hlth Inst, CH-4002 Basel, Switzerland

[6] Univ Basel, CH-4003 Basel, Switzerland

来源：

JOURNAL OF NATURAL PRODUCTS | 2013年 / 76卷 / 09期

基金：

美国国家科学基金会;

关键词：

TERPENOIDS; ACID;

D O I：

10.1021/np400337a

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A new triterpenoid, urmiensolide (1), was isolated from Salvia urmiensis. The structure was elucidated by a combination of 1D and 2D NMR, HRESIMS, and X-ray crystallographic analyses. The absolute configuration was established by comparison of experimental and simulated ECD spectra. Urmiensolide is the first pentacyclic triterpenoid bearing a epsilon-lactone E-ring. The compound showed in vitro antitrypanosoal activity with an IC50 value of 5.6 mu M against the Trypanosoma brucei rhodesiense STIB 900 strain and a selectivity index of 33. A possible biosynthetic pathway of 1 from a-amyrin is proposed.

引用

收藏

页码：1806 / 1809

页数：4

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