Invasive Pneumococcal Disease after Routine Pneumococcal Conjugate Vaccination in Children, England and Wales

被引：81
作者：
Ladhani, Shamez N. [1 ]
Slack, Mary P. E. [1 ]
Andrews, Nick J. [1 ]
Waight, Pauline A. [1 ]
Borrow, Ray [2 ]
Miller, Elizabeth [1 ]
机构：
[1] Hlth Protect Serv Colindale, London, England
[2] Hlth Protect Agcy, Manchester, Lancs, England
来源：
EMERGING INFECTIOUS DISEASES | 2013年 / 19卷 / 01期
关键词：
RISK-FACTORS; SCHEDULE; IRAK-4;
D O I：
10.3201/eid1901.120741
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
We assessed known risk factors, clinical presentation, and outcome of invasive pneumococcal disease (IPD) in children 3-59 months of age after introduction of the 7-valent pneumococcal conjugate vaccine (PCV7) in England and Wales. During September 2006 March 2010, a total of 1,342 IPD episodes occurred in 1,332 children; 14.9% (198/1,332) had comorbidities. Compared with IPD caused by PCV7 serotypes (44/248; 17.7%), comorbidities were less common for the extra 3 serotypes in the 10-valent vaccine (15/299; 5.0%) but similar to the 3 additional PCV13 serotypes (45/336; 13.4%) and increased for the 11 extra serotypes in 23-valent polysaccharide vaccine (PPV23) (39/186; 21.0%) and non-PPV23 serotypes (38/138; 27.5%). Fifty-two (3.9%) cases resulted from PCV7 failure; 9 (0.7%) case-patients had recurrent IPD. Case-fatality rate was 4.4% (58/1,332) but higher for meningitis (11.0%) and children with comorbidities (9.1%). Thus, comorbidities were more prevalent in children with IPD caused by non-PCV13 serotypes and were associated with increased case fatality.
引用
收藏
页码：61 / 68
页数：8
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