A blooming resolvase at chromosomal fragile sites

被引：8
|
作者：
Pellicioli, Achille [1 ]
Muzi-Falconi, Marco [1 ]
机构：
[1] Univ Milan, Dipartimento Biosci, I-20133 Milan, Italy
来源：
NATURE CELL BIOLOGY | 2013年 / 15卷 / 08期
关键词：
REPLICATION STRESS; INSTABILITY; COMMON; STABILITY;
D O I：
10.1038/ncb2812
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Common fragile sites (CFSs) are chromosomal regions that are prone to form breaks or gaps during mitosis, in particular following replication stress. The mechanisms modulating CFS expression and promoting safe chromatid transmission to daughter cells are not clear. Now CFS expression is shown to reflect the activity of the MUS81-EME1 resolvase complex which cooperates with the dissolving action of the BLM helicase to prevent uncontrolled chromosome breakage and to promote genome integrity.
引用
收藏
页码：883 / 885
页数：3
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