A blooming resolvase at chromosomal fragile sites

被引：8
|
作者：
Pellicioli, Achille [1 ]
Muzi-Falconi, Marco [1 ]
机构：
[1] Univ Milan, Dipartimento Biosci, I-20133 Milan, Italy
来源：
NATURE CELL BIOLOGY | 2013年 / 15卷 / 08期
关键词：
REPLICATION STRESS; INSTABILITY; COMMON; STABILITY;
D O I：
10.1038/ncb2812
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Common fragile sites (CFSs) are chromosomal regions that are prone to form breaks or gaps during mitosis, in particular following replication stress. The mechanisms modulating CFS expression and promoting safe chromatid transmission to daughter cells are not clear. Now CFS expression is shown to reflect the activity of the MUS81-EME1 resolvase complex which cooperates with the dissolving action of the BLM helicase to prevent uncontrolled chromosome breakage and to promote genome integrity.
引用
收藏
页码：883 / 885
页数：3
相关论文
共 50 条
  • [21] 3D genome organization contributes to genome instability at fragile sites
    Sarni, Dan
    Sasaki, Takayo
    Tur-Sinai, Michal Irony
    Miron, Karin
    Rivera-Mulia, Juan Carlos
    Magnuson, Brian
    Ljungman, Mats
    Gilbert, David M.
    Kerem, Batsheva
    NATURE COMMUNICATIONS, 2020, 11 (01)
  • [22] UBE2T resolves transcription-replication conflicts and protects common fragile sites in primordial germ cells
    Yu, Yongze
    Xu, Weiwei
    Wen, Canxin
    Zhao, Simin
    Li, Guangyu
    Liu, Ran
    Chen, Zi-Jiang
    Qin, Yingying
    Ma, Jinlong
    Yang, Yajuan
    Zhao, Shidou
    CELLULAR AND MOLECULAR LIFE SCIENCES, 2023, 80 (04)
  • [23] Molecular profiling of common fragile sites in human fibroblasts
    Le Tallec, Benoit
    Dutrillaux, Bernard
    Lachages, Anne-Marie
    Millot, Gael Armel
    Brison, Olivier
    Debatisse, Michelle
    NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2011, 18 (12) : 1421 - 1423
  • [24] Common Fragile Sites: Genomic Hotspots of DNA Damage and Carcinogenesis
    Ma, Ke
    Qiu, Li
    Mrasek, Kristin
    Zhang, Jun
    Liehr, Thomas
    Quintana, Luciana Goncalves
    Li, Zheng
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2012, 13 (09) : 11974 - 11999
  • [25] Role of common fragile sites and corresponding genes in cancer development
    Aqeilan, Rami I.
    CELLULAR AND MOLECULAR LIFE SCIENCES, 2014, 71 (23) : 4487 - 4488
  • [26] Role of common fragile sites and corresponding genes in cancer development
    Rami I. Aqeilan
    Cellular and Molecular Life Sciences, 2014, 71 : 4487 - 4488
  • [27] Large transcription units unify copy number variants and common fragile sites arising under replication stress
    Wilson, Thomas E.
    Arlt, Martin F.
    Park, So Hae
    Rajendran, Sountharia
    Paulsen, Michelle
    Ljungman, Mats
    Glover, Thomas W.
    GENOME RESEARCH, 2015, 25 (02) : 189 - 200
  • [28] FANCD2 Facilitates Replication through Common Fragile Sites
    Madireddy, Advaitha
    Kosiyatrakul, Settapong T.
    Boisvert, Rebecca A.
    Herrera-Moyano, Emilia
    Garcia-Rubio, Maria L.
    Gerhardt, Jeannine
    Vuono, Elizabeth A.
    Owen, Nichole
    Yan, Zi
    Olson, Susan
    Aguilera, Andres
    Howlett, Niall G.
    Schildkraut, Carl L.
    MOLECULAR CELL, 2016, 64 (02) : 388 - 404
  • [29] Inhibition of topoisomerase I prevents chromosome breakage at common fragile sites
    Arlt, Martin F.
    Glover, Thomas W.
    DNA REPAIR, 2010, 9 (06) : 678 - 689
  • [30] Translesion polymerase eta both facilitates DNA replication and promotes increased human genetic variation at common fragile sites
    Twayana, Shyam
    Bacolla, Albino
    Barreto-Galvez, Angelica
    De-Paula, Ruth B.
    Drosopoulos, William C.
    Kosiyatrakul, Settapong T.
    Bouhassira, Eric E.
    Tainer, John A.
    Madireddy, Advaitha
    Schildkraut, Carl L.
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2021, 118 (48)
12345