Local approaches to hereditary breast cancer

被引:4
作者
Cooper, B. T. [1 ]
Murphy, J. O. [2 ]
Sacchini, V. [2 ]
Formenti, S. C. [1 ]
机构
[1] NYU, Sch Med, Dept Radiat Oncol, New York, NY 10016 USA
[2] Mem Sloan Kettering Canc Ctr, Dept Surg, Breast Serv, New York, NY 10021 USA
关键词
hereditary breast cancer; radiation; BRCA1; BRCA2; radiation-induced malignancy; BRCA2 MUTATION CARRIERS; CONTRALATERAL PROPHYLACTIC MASTECTOMY; REDUCING SALPINGO-OOPHORECTOMY; SURGICAL ADJUVANT BREAST; QUALITY-OF-LIFE; FOLLOW-UP; RISK REDUCTION; PSYCHOLOGICAL REACTIONS; BODY-IMAGE; WOMEN;
D O I
10.1093/annonc/mdt327
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The diagnostic and local treatment modalities of hereditary breast cancer (HBC) are evolving based on emerging evidence from new imaging, radiotherapy and surgical studies. The optimal selection of diagnostic and therapeutic strategies for the individual HBC patient remains an area of active research in this relatively new patient population. In this context, some rational pathways of intervention are currently available to both reduce cancer risk in mutation carriers without a cancer diagnosis, as well as to reduce the risk of recurrence or new cancers among the carriers already diagnosed with a malignancy. It is encouraging to notice to what degree certain interventions have successfully reduced both the risk of malignancy and the anxiety associated with this genetic diagnosis. This updated report aims at summarizing the most recent findings, while it identifies the areas of uncertainty that remain, and continue to present difficult challenges, particularly among younger HBC patients.
引用
收藏
页码:54 / 60
页数:7
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