Raltegravir in the prevention of mother-to-child transmission of HIV-1: effective transplacental transfer and delayed plasma clearance observed in preterm neonates

被引:21
作者
Hegazi, Aseel [2 ]
Mc Keown, Denise [3 ]
Doerholt, Katja [4 ]
Donaghy, Sheila [4 ]
Sadiq, Syed T. [1 ,2 ]
Hay, Phillip [1 ,2 ]
机构
[1] St Georges Univ London, Ctr Infect & Immun, London SW17 0RE, England
[2] St Georges Healthcare NHS Trust, Dept Genitourinary Med, London, England
[3] Univ London, Analyt Unit, London, England
[4] St Georges Healthcare NHS Trust, Dept Paediat Infect Dis, London, England
关键词
TREATMENT-NAIVE PATIENTS; COMBINATION THERAPY; INFECTION; WOMEN; PHARMACOKINETICS; INHIBITOR; TENOFOVIR; SAFETY; TRIAL;
D O I
10.1097/QAD.0b013e32835a9aeb
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
引用
收藏
页码:2421 / 2423
页数:3
相关论文
共 10 条
[1]   PRINCIPLES OF DRUG BIODISPOSITION IN THE NEONATE - A CRITICAL-EVALUATION OF THE PHARMACOKINETIC-PHARMACODYNAMIC INTERFACE .1. [J].
BESUNDER, JB ;
REED, MD ;
BLUMER, JL .
CLINICAL PHARMACOKINETICS, 1988, 14 (04) :189-216
[2]   Clinical Pharmacology Profile of Raltegravir, an HIV-1 Integrase Strand Transfer Inhibitor [J].
Brainard, Diana M. ;
Wenning, Larissa A. ;
Stone, Julie A. ;
Wagner, John A. ;
Iwamoto, Marian .
JOURNAL OF CLINICAL PHARMACOLOGY, 2011, 51 (10) :1376-1402
[3]  
Cooper ER, 2002, J ACQ IMMUN DEF SYND, V29, P484, DOI 10.1097/00126334-200204150-00009
[4]   Plasma and Intracellular Tenofovir Pharmacokinetics in the Neonate (ANRS 12109 Trial, Step 2) [J].
Hirt, Deborah ;
Ekouevi, Didier K. ;
Pruvost, Alain ;
Urien, Saik ;
Arrive, Elise ;
Blanche, Stephane ;
Avit, Divine ;
Amani-Bosse, Clarisse ;
Nyati, Mandisa ;
Legote, Shini ;
Ek, Meng L. ;
Say, Leakhena ;
McIntyre, James ;
Dabis, Francois ;
Treluyer, Jean-Marc .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2011, 55 (06) :2961-2967
[5]   Safety and efficacy of raltegravir-based versus efavirenz-based combination therapy in treatment-naive patients with HIV-1 infection: a multicentre, double-blind randomised controlled trial [J].
Lennox, Jeffrey L. ;
Dejesus, Edwin ;
Lazzarin, Adriano ;
Pollard, Richard B. ;
Ramalho Madruga, Jose Valdez ;
Berger, Daniel S. ;
Zhao, Jing ;
Xu, Xio ;
Williams-Diaz, Angela ;
Rodgers, Anthony J. ;
Barnard, Richard J. O. ;
Miller, Michael D. ;
DiNubile, Mark J. ;
Nguyen, Bach-Yen ;
Leavitt, Randi ;
Sklar, Peter .
LANCET, 2009, 374 (9692) :796-806
[6]   Rapid and durable Antiretroviral effect of the HIV-1 integrase inhibitor raltegravir as part of combination therapy in treatment-naive patients with HIV-1 infection - Results of a 48-week controlled study [J].
Markowitz, Martin ;
Nguyen, Bach-Yen ;
Gotuzzo, Eduardo ;
Mendo, Fernando ;
Ratanasuwan, Winai ;
Kovacs, Colin ;
Prada, Guillermo ;
Morales-Ramirez, Javier O. ;
Crumpacker, Clyde S. ;
Isaacs, Robin D. ;
Gilde, Lucinda R. ;
Wan, Hong ;
Miller, Michael D. ;
Wenning, Larissa A. ;
Teppler, Hedy .
JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, 2007, 46 (02) :125-133
[7]   High neonatal concentrations of raltegravir following transplacental transfer in HIV-1 positive pregnant women [J].
Mckeown, Denise A. ;
Rosenvinge, Melanie ;
Donaghy, Sheila ;
Sharland, Mike ;
Holt, David W. ;
Cormack, Ian ;
Phillip, Hay ;
Sadiq, S. Tariq .
AIDS, 2010, 24 (15) :2416-2418
[8]   A phase I/II study of the safety and pharmacokinetics of nevirapine in HIV-1-infected pregnant Ugandan women and their neonates (HIVNET 006) [J].
Musoke, P ;
Guay, LA ;
Bagenda, D ;
Mirochnick, M ;
Nakabiito, C ;
Fleming, T ;
Elliott, T ;
Horton, S ;
Dransfield, K ;
Pav, JW ;
Murarka, A ;
Allen, M ;
Fowler, MG ;
Mofenson, L ;
Hom, D ;
Mmiro, F ;
Jackson, JB .
AIDS, 1999, 13 (04) :479-486
[9]   Rapid HIV-RNA decline following addition of raltegravir and tenofovir to ongoing highly active antiretroviral therapy in a woman presenting with high-level HIV viraemia at week 38 of pregnancy [J].
Pinnetti, Carmela ;
Baroncelli, Silvia ;
Villani, Paola ;
Fantoni, Massimo ;
Tozzi, Valerio ;
De Luca, Andrea ;
Cauda, Roberto ;
Anzidei, Gianfranco ;
Cusato, Maria ;
Regazzi, Mario ;
Floridia, Marco ;
Tamburrini, Enrica .
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2010, 65 (09) :2050-2052
[10]   THE EFFECT OF HUMAN-IMMUNODEFICIENCY-VIRUS INFECTION ON BIRTH-WEIGHT, AND INFANT AND CHILD-MORTALITY IN URBAN MALAWI [J].
TAHA, TE ;
DALLABETTA, GA ;
CANNER, JK ;
CHIPHANGWI, JD ;
LIOMBA, G ;
HOOVER, DR ;
MIOTTI, PG .
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, 1995, 24 (05) :1022-1029